Results 41 to 50 of about 2,690,569 (319)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Dynamic Safety Assessment in Nonlinear Hydropower Generation Systems

Complexity, 2018
This paper focuses on the stability problems in a hydropower station. To enable this study, we consider a nonlinear hydropower generation system for the load rejection transient process based on an existing hydropower station.
Shuang Li, Yong Yang, Qing Xia
doaj   +1 more source

Evaluation methods of elastoplastic response of components to earthquake motions (Dynamic Analysis of MDOF Systems using elastoplastic response spectrum)

Nihon Kikai Gakkai ronbunshu, 2017
For seismic design of components, elastic response spectrum analysis, which is based on linear response using elastic response spectrum, is generally used as a dynamic analysis of multi-degree-of-freedom(MDOF) systems not only elastic response but also ...
Ichiro TAMURA, Shinichi MATSUURA
doaj   +1 more source

Recent advances on information transmission and storage assisted by noise

, 2013
The interplay between nonlinear dynamic systems and noise has proved to be of great relevance in several application areas. In this presentation, we focus on the areas of information transmission and storage.
A Dari, A Dari, A Sawa, A Stotland, AR Bulsara, B McNamara, B Mensour, B Mensour, CE Korman, D Guerra, DB Strukov, F Chapeau-Blondeau, F Chapeau-Blondeau, F Duan, F Gomez-Marlasca, G Bellomo, J García-Ojalvo, J Losson, JF Lindner, JW Middleton, K Murali, K Murali, KP Singh, L Chua, L Chua, L Gammaitoni, M Löcher, M.F. Carusela, MD Pickett, MF Carusela, MJ Rozenberg, MJ Sánchez, N Ghenzi, N Ghenzi, P Dutta, R Morse, R Perazzo, S Barbay, S Barbay, T Aida, X Godivier, Y Jin, Y Zhang, YN Joglekar   +43 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

Identification of Nonlinear Systems Using Radial Basis Function Neural Network [PDF]

, 2014
This paper uses the radial basis function neural network (RBFNN) for system identification of nonlinear systems. Five nonlinear systems are used to examine the activity of RBFNN in system modeling of nonlinear systems; the five nonlinear systems are ...
Pislaru, Crinela, Shebani, Amer
core   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Logic-dynamic approach to fault diagnosis in mechatronic systems

International Journal of Advanced Robotic Systems, 2008
This paper presents a problem of fault detection and isolation (FDI) in mechatronic systems described by nonlinear dynamic models with such types of no differentiable nonlinearities as saturation, Coulomb friction, backlash, and hysteresis. To solve this
A. N. Zhirabok, V. F. Filaretov
doaj