Results 181 to 190 of about 366,215 (335)

Implicit Central Difference Approximations of Averaged Dynamics of Highly Oscillatory Systems With Applications to Direct Optimal Control

open access: yesOptimal Control Applications and Methods, EarlyView.
Trajectory optimization of highly oscillatory systems can require huge computational efforts if the horizon of the problem is much larger than the duration of a single cycle. To alleviate this effort, stroboscopic averaging methods can be used, which utilize local single‐cycle simulations of the oscillatory dynamics, to then approximate and integrate ...
Jakob Harzer   +3 more
wiley   +1 more source

Characterization of structural properties and non‐linear rheological behavior of collagen over a wide range of mass fractions under LAOS

open access: yesPolymer Engineering &Science, EarlyView.
Significant novelty in the collagen research has been provided by the characterization of its structural properties and non‐linear behavior in dependence over a wide range of mass fraction. These experiments helped to understand the behavior of viscoelastic biopolymers during their production process, which is happening under high shear rates. Abstract
Jan Štípek   +7 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Model of Tyrosine Kinase Inhibitors to Predict Target Site Penetration, with PET‐Guided Verification

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Osimertinib, a tyrosine kinase inhibitor (TKI), treats non‐small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. However, its efficacy may vary due to heterogeneous drug distribution, assessable through microdosed radiolabeled drugs and positron emission tomography (PET).
Suzanne van der Gaag   +13 more
wiley   +1 more source

Relation of Bulk‐to‐Shear Loss Factors in Viscoelastic Auxetic Metamaterials

open access: yesphysica status solidi (b), EarlyView.
This article examines the dynamic behavior of isotropic auxetic viscoelastic materials, highlighting how negative Poisson's ratios affect energy dissipation, damping, and the interplay between bulk and shear moduli. By extending established viscoelastic theories to the auxetic range, it defines bound limits and underscores how dynamic Poisson's ratio ...
Simon Preston   +2 more
wiley   +1 more source

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