Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Complete Integrability of Nonlinear Evolution Equations [PDF]
Summary: It is shown that a broad class of nonlinear evolution equations, which have been systematically discussed by Ablowitz, Kaup, Newell and Segur, can be described as the Hamiltonian systems and that these Hamiltonian systems are completely integrable.
openaire +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Approximate Solutions of Nonlinear Integral Equations Using the Cubic B-Spline Scaling Method
This paper examines a category of general nonlinear integral equations. These equations also include many special cases, such as functional equations and nonlinear integral equations of the Volterra type.
Mohammed Jabbar Adaay Al-Sharea
doaj +1 more source
ON NONLINEAR INTEGRAL EQUATIONS WITH DEVIATING ARGUMENTS
We prove an existence theorem for a class of nonlinear inte- gral equations with deviating arguments.
Balachandran, K., Ilamaran, S.
openaire +3 more sources
Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane +10 more
wiley +1 more source
Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park +5 more
wiley +1 more source
On integrability of nonautonomous nonlinear Schrödinger equations [PDF]
We show, in general, how to transform the nonautonomous nonlinear Schrödinger equation with quadratic Hamiltonians into the standard autonomous form that is completely integrable by the familiar inverse scattering method in nonlinear science. Derivation of the corresponding equivalent nonisospectral Lax pair is also outlined.
openaire +3 more sources
Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis
Objective Rheumatoid arthritis (RA) is associated with an increased risk of frailty and osteoporosis, but the relationship between frailty and incident osteoporotic fractures in RA is underexplored. Methods Data were from the Veterans Affairs (VA) Rheumatoid Arthritis Registry. Frailty was measured using the VA Frailty Index (VAFI).
Katherine D. Wysham +14 more
wiley +1 more source

