Results 71 to 80 of about 640,764 (331)

Predicting Height to Crown Base of Larix olgensis in Northeast China Using UAV-LiDAR Data and Nonlinear Mixed Effects Models

Remote Sensing, 2021
As a core content of forest management, the height to crown base (HCB) model can provide a theoretical basis for the study of forest growth and yield.
Xin Liu, Yuanshuo Hao, Faris Rafi Almay Widagdo, L. Xie, Lihu Dong, Fengri Li   +5 more
semanticscholar   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A new method for the estimation of variance matrix with prescribed zeros in nonlinear mixed effects models [PDF]

, 2008
We propose a new method for the Maximum Likelihood Estimator (MLE) of nonlinear mixed effects models when the variance matrix of Gaussian random effects has a prescribed pattern of zeros (PPZ).
A.P. Dempster, C.F. Wu, D. Concordet, D.L. Zimmerman, Didier Concordet, Djalil Chafaï, E. Kuhn, E.C. Cepeda, E.F. Vonesh, H. Ye, J. Wang, J.C. Pinheiro, M. Davidian, M. Drton, M. Jamshidian, M. Pourahmadi, M. Pourahmadi, M.J. Lindstrom, R.A. Horn, R.D. Wolfinger, R.D. Wolfinger, S. Chaudhuri, T.W. Anderson   +22 more
core   +4 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Incorporating stand parameters in nonlinear height-diameter mixed-effects model for uneven-aged Larix gmelinii forests

Frontiers in Forests and Global Change
Tree attributes, such as height (H) and diameter at breast height (D), are essential for predicting forest growth, evaluating stand characteristics and developing yield models for sustainable forest management.
Muhammad Junaid Ismail, Tika Ram Poudel, Akber Ali, Lingbo Dong   +3 more
doaj   +1 more source

Development of stem diameter model for Bornmullerian fir (Abies nordmanniana (Stev.) subsp. bornmulleriana (Mattf.)) stands in Ayancık District using mixed effects modeling approach

Turkish Journal of Forestry, 2015
A nonlinear mixed-effect modeling approach was used to model for Turkish fir [Abies nordmanniana (Stev.) subsp. bornmülleriana (Mattf.)] stands in Sinop-Ayancık District of Turkey.
Ramazan ÖZÇELİK, Ümit YAŞAR
doaj   +1 more source

Understanding nonlinear and synergistic effects of the built environment on urban vibrancy in metro station areas

Journal of Engineering and Applied Science, 2023
Transit-oriented development (TOD) has long been recognized as a significant model for prospering urban vibrancy. However, most studies on TOD and urban vibrancy do not consider temporal differences or the nonlinear effects involved.
Jiandong Peng, Yiwen Hu, Chao Liang, Qiuyu Wan, Qi Dai, Hong Yang   +5 more
doaj   +1 more source

Nonlinear mixed-effects growth models: A tutorial using 'saemix' in R

Methodology, 2021
Modeling growth across repeated measures of individuals and evaluating predictors of growth can reveal developmental patterns and factors that affect those patterns.
Peter Boedeker
semanticscholar   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Spike-and-Slab Priors for Function Selection in Structured Additive Regression Models

, 2011
Structured additive regression provides a general framework for complex Gaussian and non-Gaussian regression models, with predictors comprising arbitrary combinations of nonlinear functions and surfaces, spatial effects, varying coefficients, random ...
Fabian Scheipl, Fahrmeir L., Hothorn T., Lewis B., Ludwig Fahrmeir, Polson N., Sabanés Bové D., Scheipl F., Scheipl F., Scheipl F., Thomas Kneib   +10 more
core   +1 more source