From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot +3 more
wiley +1 more source
Transient flow and heat transfer of CuO-Al<sub>2</sub>O<sub>3</sub>/H<sub>2</sub>O hybrid nanofluid flow over a radially stretching surface with dissipation and ohmic heating. [PDF]
Ragavi M, Poornima T, Sreenivasulu P.
europepmc +1 more source
Transient Cytoskeletal Anisotropy Encodes Short‐Term Mechanical Memory in Glioblastoma Cells
The same mechanical deformation can produce distinct cytoskeletal states depending on loading history. Experiments and constitutive modeling reveal that transient actin–vimentin anisotropy stores mechanical information and governs short‐term mechanical memory in glioblastoma cells.
Clara Gomez‐Cruz +5 more
wiley +1 more source
Computational study to heat and mass transfer analysis of blood-based Maxwell ternary hybrid nanofluid with nonlinear thermal radiation and exponential heat source. [PDF]
Mahariq I +7 more
europepmc +1 more source
Understanding Operando Water Management in Hydroxide‐Exchange‐Membrane Fuel Cells
Effective water management is vital for high‐performance hydroxide‐exchange‐membrane fuel cells. Using a custom water‐flux station, this study quantifies how membrane thickness, microporous layers, and operating conditions dictate internal water transport.
Catherine M. Weiss +4 more
wiley +1 more source
Innovative solutions for lossy nonlinear transmission lines model using a modified extended mapping approach with fractional effects. [PDF]
Hussein HH, Alexan W, Kandil SA.
europepmc +1 more source
A vacuum‐free, ambient‐spray Ni–Cu(–O)/Ag nanowire transparent‐heater platform is realized via conformal junction‐shell engineering and silica–hybrid overcoating, enabling robust high‐temperature heating together with GHz‐band far‐field EMI shielding and near‐field magnetic‐noise attenuation.
Ye Na Heo +4 more
wiley +1 more source
Significance of oscillatory TiO<sub>2</sub>-water nanofluid and heat transfer performance over vertical magnetized flat plate using artificial neural network. [PDF]
Ullah Z +7 more
europepmc +1 more source
Two‐Way Shape Memory Polymer Composite Gripper for Adaptive Robotic Applications
A two‐way shape memory polymer (SMP) composite is developed with intrinsic shape‐changing capability driven solely by temperature, eliminating external actuation loads. Embedding the SMP in a low‐stiffness elastomeric matrix enabled reversible transformations during heating and cooling cycles.
Aamna Hameed, Kamran Ahmed Khan
wiley +1 more source
A flexible piezoresistive pressure sensor with gradient toroidal CNT/PDMS microstructures is reported. The hierarchical geometry enables sequential electrode contact, achieving a sensitivity of 256.20 kPa−1 and linear response (R2 = 0.99) over 0–1000 kPa.
Rongmei Wang +8 more
wiley +1 more source

