Results 41 to 50 of about 327,222 (277)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

The Existence and Uniqueness of the Solution of a Nonlinear Partial Differential Equation in the Eontinuous Functions of Holder and Sobolev Spaces

پژوهش‌های ریاضی, 2020
Introduction Complex analysis is a comparatively active branch in mathematics which has grown significantly. A deep look at the implications of continuity, derivative and integral in complex analysis and their relation with partial differential equations
Mozhgan Akbari, Fateme Joveini
doaj  

On the geometric structure of characteristic vector fields related with nonlinear equations of the Hamilton-Jacobi type [PDF]

Opuscula Mathematica, 2007
The Cartan-Monge geometric approach to the characteristics method for Hamilton-Jacobi type equations and nonlinear partial differential equations of higher orders is analyzed.
Natalia K. Prykarpatska, Eugeniusz Wachnicki   +1 more
doaj  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The solutions of nonlinear fractional partial differential equations by using a novel technique

Open Physics, 2022
In this article, the solutions of higher nonlinear partial differential equations (PDEs) with the Caputo operator are presented. The fractional PDEs are modern tools to model various phenomena more accurately.
Alderremy Aisha Abdullah, Khan Hassan, Khan Qasim, Kumam Poom, Aly Shaban, Ahmad Said, Sitthithakerngkiet Kanokwan   +6 more
doaj   +1 more source

Global and Regional Temporal Changes in Cross‐Country Inequalities of Site‐Specific Osteoarthritis Burden, 1990 to 2021

Arthritis Care &Research, EarlyView.
Objective This study examined the global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis (OA) burden from 1990 to 2021. Methods Age‐standardized years lived with disability rates (ASYRs) for site‐specific OA across 204 countries and territories were obtained from the Global Burden of Diseases, Injuries, and ...
Haowei Chen, Lei Si, David J. Hunter, Lei Zhang, Zhe‐Sheng Chen, Xiaomeng Wang, Vicky Duong, Zhounan Zhou, Peihua Cao, Han Cen, Su'an Tang, Tianyu Chen, Houjun Xue, Zhaohua Zhu, Changhai Ding   +14 more
wiley   +1 more source

Partially integrable systems in multidimensions by a variant of the dressing method. 1

, 2006
In this paper we construct nonlinear partial differential equations in more than 3 independent variables, possessing a manifold of analytic solutions with high, but not full, dimensionality. For this reason we call them ``partially integrable''.
A I Zenchuk, Ablowitz M J, Ablowitz M J, Beals R Coifman R R, Bogdanov L V, Calogero F, Drinfeld V G, Konopelchenko B, Manakov S V Santini P M, P M Santini, Zakharov V E, Zakharov V E, Zakharov V E, Zakharov V E, Zakharov V E, Zakharov V E, Zenchuk A   +16 more
core   +1 more source

Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over

Arthritis Care &Research, EarlyView.
Objective Reports have linked both high and low serum uric acid (SUA) levels to adverse health outcomes. This study aimed to establish a reference interval for SUA in older adults and assessed its association with clinically relevant outcomes in relatively healthy, community‐dwelling individuals aged ≥70 years old.
Amanda J. Rickard, Cammie Tran, Hans G. Schneider, Flavia M. Cicuttini, Anita E. Wluka, Ego Seeman, Johannes T. Neumann, Md Nazmul Karim, Zhen Zhou, Sultana Monira Hussain, David P. Q. Clark, Daniel Clayton‐Chubb, Andrew M. Tonkin, Lawrence J. Beilin, Robyn L. Woods, John J. McNeil   +15 more
wiley   +1 more source

Penalization method for a nonlinear Neumann PDE via weak solutions of reflected SDEs

, 2013
In this paper we prove an approximation result for the viscosity solution of a system of semi-linear partial differential equations with continuous coefficients and nonlinear Neumann boundary condition. The approximation we use is based on a penalization
Bahlali, Khaled, Maticiuc, Lucian, Zalinescu, Adrian   +2 more
core   +3 more sources

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

Arthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source