Results 61 to 70 of about 433,700 (300)

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

On nonlinear fractional Schrodinger equation with indefinite potential and Hardy potential [PDF]

, 2022
Heilong Mi, Wen Zhang, Fangfang Liao
openalex   +1 more source

Soliton Resolution for the Derivative Nonlinear Schrödinger Equation [PDF]

, 2017
We study the derivative nonlinear Schrödinger equation for generic initial data in a weighted Sobolev space that can support bright solitons (but exclude spectral singularities).
R. Jenkins, Jiaqi Liu, P. Perry, C. Sulem   +3 more
semanticscholar   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Riemann–Hilbert approach and N-soliton solution for an eighth-order nonlinear Schrödinger equation in an optical fiber

Advances in Difference Equations, 2019
This paper aims to present an application of the Riemann–Hilbert approach to treat higher-order nonlinear differential equation that is an eighth-order nonlinear Schrödinger equation arising in an optical fiber. Starting from the spectral analysis of the
Zhou-Zheng Kang, Tie-Cheng Xia, Wen-Xiu Ma   +2 more
doaj   +1 more source

Solitary wave solutions of the Camassa–Holm-Nonlinear Schrödinger Equation

Results in Physics, 2020
This study investigates the solitary wave solutions to the defocusing nonlinear Schrödinger equation, which is known as Camassa–Holm-Nonlinear Schrödinger (CH-NLS) equation.
Thilagarajah Mathanaranjan
doaj   +1 more source

Jacobi elliptic function approach to a conformable fractional nonlinear Schrödinger–Hirota equation

Partial Differential Equations in Applied Mathematics, 2023
In this present paper we propound the following equation iDtαu+a2Dx2αu+ia3Dx3αu+a4Dx4α+ibDxα|u|2u+iσ|u|2Dxαu+iλDxα|u|2=c1|u|2u+c2|u|4,which is called the generalized nonlinear fractional Schrödinger–Hirota equation with conformable derivative.
Ahmad Sharif
doaj   +1 more source

Universality of the Peregrine Soliton in the Focusing Dynamics of the Cubic Nonlinear Schrödinger Equation. [PDF]

Physical Review Letters, 2017
We report experimental confirmation of the universal emergence of the Peregrine soliton predicted to occur during pulse propagation in the semiclassical limit of the focusing nonlinear Schrödinger equation.
A. Tikan, C. Billet, G. El, A. Tovbis, M. Bertola, T. Sylvestre, F. Gustave, S. Randoux, G. Genty, P. Suret, J. Dudley   +10 more
semanticscholar   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source