Results 51 to 60 of about 138,910 (273)

Optimization of identifiability for efficient community detection

New Journal of Physics, 2020
Many physical and social systems are best described by networks. And the structural properties of these networks often critically determine the properties and function of the resulting mathematical models.
Hui-Jia Li, Lin Wang, Yan Zhang, Matjaž Perc   +3 more
doaj   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Discriminatively Constrained Semi-Supervised Multi-View Nonnegative Matrix Factorization with Graph Regularization

Big Data Mining and Analytics
Nonnegative Matrix Factorization (NMF) is one of the most popular feature learning technologies in the field of machine learning and pattern recognition. It has been widely used and studied in the multi-view clustering tasks because of its effectiveness.
Guosheng Cui, Ye Li, Jianzhong Li, Jianping Fan   +3 more
doaj   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

SPN graphs: when copositive=SPN

, 2016
A real symmetric matrix $A$ is copositive if $x^TAx\ge 0$ for every nonnegative vector $x$. A matrix is SPN if it is a sum of a real positive semidefinite matrix and a nonnegative one.
Shaked-Monderer, Naomi
core   +1 more source

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

Advanced Science, EarlyView.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang, Wenjing Zhang, Hang Wei, Shiyan Liu, Junliang Shang, Weijie Gong, Hanwen Cheng, Xiujuan Lei, Yuhui Kou, Baoguo Jiang   +9 more
wiley   +1 more source

Speech Enhancement Control Design Algorithm for Dual-Microphone Systems Using β-NMF in a Complex Environment

Complexity, 2018
Single-microphone speech enhancement algorithms by using nonnegative matrix factorization can only utilize the temporal and spectral diversity of the received signal, making the performance of the noise suppression degrade rapidly in a complex ...
Dong-xia Wang, Mao-song Jiang, Fang-lin Niu, Yu-dong Cao, Cheng-xu Zhou   +4 more
doaj   +1 more source

Boolean Matrix Factorization via Nonnegative Auxiliary Optimization

IEEE Access, 2021
A novel approach to Boolean matrix factorization (BMF) is presented. Instead of solving the BMF problem directly, this approach solves a nonnegative optimization problem with an additional constraint over an auxiliary matrix whose Boolean structure is ...
Duc P. Truong, Erik Skau, Derek Desantis, Boian Alexandrov   +3 more
doaj   +1 more source

Graph‐based imitation and reinforcement learning for efficient Benders decomposition

AIChE Journal, EarlyView.
Abstract This work introduces an end‐to‐end graph‐based agent for accelerating the computational efficiency of Benders Decomposition. The agent's policy is parameterized by a graph neural network, which takes as input a bipartite graph representation of the master problem and proposes a candidate solution.
Bernard T. Agyeman, Zhe Li, Ilias Mitrai, Prodromos Daoutidis   +3 more
wiley   +1 more source