Results 121 to 130 of about 724,098 (319)

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

open access: yesAdvanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes   +11 more
wiley   +1 more source

Nonparametric Estimation IV

open access: yesThe Annals of Mathematical Statistics, 1951
In the three papers, [1], [2], [3], entitled "Nonparametric estimation", Scheffe and Tukey generalized previous results on tolerance regions and extended them to cover all continuous and discontinuous distribution functions. This note contains four comments arising from these papers: first, on a method for giving bounds to the confidence level in the ...
Fraser, D. A. S., Wormleighton, R.
openaire   +2 more sources

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang   +9 more
wiley   +1 more source

THE RELATIONSHIP BETWEEN FAMILY SUPPORT AND SOCIAL SUPPORT WITH DIET ADHERENCE OF HYPERTENSIVE PATIENTS

open access: yesJournal of Vocational Nursing
Introduction: Hypertension is an escalating global health issue, with diet playing a critical role in its management by limiting salt and saturated fat intake while increasing the consumption of fruits, vegetables, and fiber.
Hesti Norma Sari   +3 more
doaj   +1 more source

Nonparametric estimation of simplified vine copula models: comparison of methods

open access: yesDependence Modeling, 2017
In the last decade, simplified vine copula models have been an active area of research. They build a high dimensional probability density from the product of marginals densities and bivariate copula densities.
Nagler Thomas   +2 more
doaj   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

open access: yesAdvanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben   +4 more
wiley   +1 more source

Does Rational Bubbles Exist in the Taiwan Stock Market? Evidence from a Nonparametric Cointegration Test [PDF]

open access: yes
In this study, we revisit the issue as to the presence of rational bubbles in the Taiwan stock market during the June 1991 to February 2005 period using the Bierens (1997) nonparametric cointegration tests.
Chi-Wei Su   +3 more
core  

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

open access: yesAdvanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou   +14 more
wiley   +1 more source

Prediction and Monitoring Method for Breast Cancer: A Case Study for Data from the University Hospital Centre of Coimbra

open access: yesCancer Management and Research, 2020
Jin Yue, 1, 2,* Na Zhao, 3,* Liu Liu 1 1School of Mathematics and VC & VR Key Laboratory of Sichuan Province, Sichuan Normal University, Chengdu, People’s Republic of China; 2School of Mathematics, Sichuan University of Arts and Science ...
Yue J, Zhao N, Liu L
doaj  

Bayesian nonparametric estimators derived from conditional Gibbs structures [PDF]

open access: yes
We consider discrete nonparametric priors which induce Gibbs-type exchangeable random partitions and investigate their posterior behavior in detail.
Antonio Lijoi   +2 more
core  

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