Results 151 to 160 of about 22,159 (266)

Dissociable Handwriting Domains in Parkinson's Disease?

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Handwriting abnormalities in Parkinson's disease (PD) extend beyond classical micrographia and may involve multiple graphomotor domains with distinct clinical and mechanistic correlates. Objectives To investigate whether distinct handwriting domains demonstrate dissociable relationships with differential diagnostic performance ...
Beyza Nur Cetin   +3 more
wiley   +1 more source

Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

open access: yesMovement Disorders, EarlyView.
Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao   +8 more
wiley   +1 more source

Ursodeoxycholic Acid and Parkinson's Disease Risk: An Emulated Target Trial in UK Electronic Health Records

open access: yesMovement Disorders, EarlyView.
Abstract Background Ursodeoxycholic acid (UDCA) has shown mitochondrial and neuroprotective effects and has been proposed as a treatment for Parkinson's disease (PD). However, population‐level evidence on its effect on PD risk is lacking. Objectives To compare the risk of incident PD among UDCA initiators versus matched non‐initiators within a ...
Chengsheng Ju   +7 more
wiley   +1 more source

Optimal Experimental Design for Fast and Accurate Relaxation Time Measurements in Magnetic Resonance

open access: yesMagnetic Resonance in Chemistry, EarlyView.
We apply D‐optimal experimental design to relaxation constant estimation in NMR relaxometry. The resulting sampling schedules concentrate measurements where the signal is most sensitive to the relaxation constant. Compared with conventional linear or logarithmic spacing, D‐optimal designs achieve better estimation accuracy and precision with fewer ...
Natalie E. Klein   +4 more
wiley   +1 more source

A Supervised Learning Framework for Accelerating Solvers and Metaheuristics in Routing Problems

open access: yesNetworks, EarlyView.
ABSTRACT Routing problems such as the traveling salesman problem (TSP) and the capacitated vehicle routing problem (CVRP) are computationally challenging due to the exponential growth of their feasible solution spaces with increasing instance size.
Johannes Gückel   +2 more
wiley   +1 more source

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