Results 61 to 70 of about 23,658 (304)

On the development of a semi-nonparametric generalized multinomial logit model for travel-related choices. [PDF]

PLoS ONE, 2017
A semi-nonparametric generalized multinomial logit model, formulated using orthonormal Legendre polynomials to extend the standard Gumbel distribution, is presented in this paper.
Ke Wang, Xin Ye, Ram M Pendyala, Yajie Zou   +3 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Nonparametric density estimation using a multidimensional mixture model of Gaussian distributions

Lietuvos Matematikos Rinkinys, 2005
This paper algorithmically and empirically studies five major types of nonparametric multivariate density estimation techniques, where no assumption is made about data being drawn from any of known parametric families of distribution. There is developed
Tomas Ruzgas, Mindaugas Kavaliauskas
doaj   +3 more sources

Nonparametric Method for Modeling Clustering Phenomena in Emergency Calls Under Spatial-Temporal Self-Exciting Point Processes

IEEE Access, 2019
In this paper, a nonparametric spatial-temporal self-exciting point process is proposed to model clustering features in emergency calls. Gaussian kernel density functions are considered.
Chenlong Li, Zhanjie Song, Xu Wang
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Probability density estimation from optimally condensed data samples [PDF]

, 2003
The requirement to reduce the computational cost of evaluating a point probability density estimate when employing a Parzen window estimator is a well-known problem.
Chao, H., Girolami, M.
core   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Empirical Density Estimation for Interval Censored Data

Austrian Journal of Statistics, 2016
This paper is concerned with the nonparametric estimation of a density function when the data are incomplete due to interval censoring. The Nadaraya-Watson kernel density estimator is modified to allow description of such interval data.
Eugenia Stoimenova
doaj   +1 more source

Estimation of The Intensity Function of Non-Homogeneous Poisson Process Using Non-Parametric Density Estimation Methods [PDF]

The Egyptian Statistical Journal, 1991
This paper presents a contribution in the non-parametric estimation of the intensity function of non-homogeneous Poison process from the practical point of view. The cumulative distribution functions of the times of successive events are obtained and the
Abdullah Al-Harby, Tarik Amira, Mohamed Habib   +2 more
doaj   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source