Results 81 to 90 of about 231,426 (276)

Adaptive orthogonal series estimation in additive stochastic regression models [PDF]

In this paper, we consider additive stochastic nonparametric regression models. By approximating the nonparametric components by a class of orthogonal series and using a generalized cross-validation criterion, an adaptive and simultaneous estimation ...
Howell Tong, Jiti Gao, Rodney C Wolff
core   +1 more source

Nonparametric Renewal Function Estimation

The Annals of Statistics, 1986
The renewal function is a basic tool used in many probabilistic models and sequential analysis. Based on a random sample of size n, a nonparametric estimator of the renewal function is introduced. Asymptotic properties of the estimator such as consistency and asymptotic normality are developed.
openaire   +3 more sources

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Nonparametric Method for Modeling Clustering Phenomena in Emergency Calls Under Spatial-Temporal Self-Exciting Point Processes

IEEE Access, 2019
In this paper, a nonparametric spatial-temporal self-exciting point process is proposed to model clustering features in emergency calls. Gaussian kernel density functions are considered.
Chenlong Li, Zhanjie Song, Xu Wang
doaj   +1 more source

Long‐Term Elevated CO2 Improves Soil Health and Rice Yields in Paddy Fields

Advanced Science, EarlyView.
Combining the two longest‐running rice free‐air CO2 enrichment experiments with a global data synthesis, this study demonstrates that long‐term elevated CO2 consistently enhances soil health. In rice paddies, this improvement sustains the CO2 fertilization effect over decades.
Fan Jiang, Wenchao Du, Kees Jan van Groenigen, Josep Peñuelas, Scott X. Chang, Lian Song, Chuang Cai, Yu Wang, Lin Deng, Zhengkun Hu, Weishou Shen, Qicong Wu, Haiyang Yu, Ying Yin, Fuxun Ai, Wei Zhou, Dongming Wang, Jianqiang Sun, Xiaoyuan Yan, Renfang Shen, Jiabao Zhang, Hongyan Guo, Chunwu Zhu   +22 more
wiley   +1 more source

Efficiency of Average Treatment Effect Estimation When the True Propensity Is Parametric

Econometrics, 2019
It is well known that efficient estimation of average treatment effects can be obtained by the method of inverse propensity score weighting, using the estimated propensity score, even when the true one is known.
Kyoo il Kim
doaj   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Estimation of semiparametric stochastic frontiers under shape constraints with application to pollution generating technologies [PDF]

A number of studies have explored the semi- and nonparametric estimation of stochastic frontier models by using kernel regression or other nonparametric smoothing techniques. In contrast to popular deterministic nonparametric estimators, these approaches
Kortelainen, Mika
core   +1 more source

Nonparametric Change-Point Estimation

The Annals of Statistics, 1988
Consider a sequence of independent random variables $\{X_i: 1 \leq i \leq n\}$ having cdf $F$ for $i \leq \theta n$ and cdf $G$ otherwise. A class of strongly consistent estimators for the change-point $\theta \in (0, 1)$ is proposed. The estimators require no knowledge of the functional forms or parametric families of $F$ and $G$. Furthermore, $F$ and
openaire   +3 more sources

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source