Results 91 to 100 of about 43,974 (259)

A Comparison of Methods for Poisson Regression in the Presence of Background

The Astrophysical Journal
This paper provides a statistical analysis of three common methods of regression for Poisson data in the presence of Poisson background, namely the joint fit with two parametric models for the source and the background, the use of a nonparametric model ...
Massimiliano Bonamente, Vinay Kashyap, Xiaoli Li, Jelle de Plaa   +3 more
doaj   +1 more source

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Modified Randomization Tests for Nonparametric Hypotheses

The Annals of Mathematical Statistics, 1957
Suppose $X_1, \cdots, X_m, Y_1, \cdots, Y_n$ are $m + n = N$ independent random variables, the $X$'s identically distributed and the $Y$'s identically distributed, each with a continuous cdf. Let $$z = (z_1, \cdots, z_m, z_{m + 1}, \cdots, z_N) = (x_1, \cdots, x_m, y_1, \cdots, y_n)$$ represent an observation on the $N$ random variables and let $$u(z) =
openaire   +3 more sources

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Statistical inference methods for n‐dimensional hypervolumes: Applications to niches and functional diversity

Methods in Ecology and Evolution
The size and shape of niche spaces or trait spaces are often analysed using hypervolumes estimated from data. The hypervolume R package has previously supported such analyses via descriptive but not inferential statistics. This gap has limited the use of
Daniel Chen, Alex Laini, Benjamin Wong Blonder   +2 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

melt: Multiple Empirical Likelihood Tests in R

Journal of Statistical Software
Empirical likelihood enables a nonparametric, likelihood-driven style of inference without relying on assumptions frequently made in parametric models.
Eunseop Kim, Steven N. MacEachern, Mario Peruggia   +2 more
doaj   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Non-Parametric Hypothesis Testing for Used Better than Aged in Laplace Transform (UBAL) Life Distributions: A Moment Inequalities Approach with Medical Applications

Axioms
Life distribution comparison is important in reliability and survival analysis to model system aging and longevity. The article develops a non-parametric hypothesis test procedure for testing exponentiality against the Used Better than Aged in Laplace ...
Mahmoud E. Bakr, Oluwafemi Samson Balogun, Arwa M. Alsahangiti, Asmaa A. El-Toony   +3 more
doaj   +1 more source