Results 131 to 140 of about 442,883 (292)

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

DEVELOPMENT OF NONPARAMETRIC PATH FUNCTION USING HYBRID TRUNCATED SPLINE AND KERNEL FOR MODELING WASTE-TO-ECONOMIC VALUE BEHAVIOR

Barekeng
Waste management remains a challenge, including in Batu City, East Java, Indonesia. Rapid population growth and economic activities in the city have resulted in a substantial increase in waste volume.
Usriatur Rohma, Adji Achmad Rinaldo Fernandes, Suci Astutik, Solimun Solimun   +3 more
doaj   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Nonparametric methods for the characteristic model [PDF]

Characteristics models have been found to be useful in many areas of economics. However, their empirical implementation tends to rely heavily on functional form assumptions.
Ian Crawford, Laura Blow, Martin Browning   +2 more
core  

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Nonparametric additive models [PDF]

, 2012
Jeffrey S. Racine, Liangjun Su, Aman Ullah, Joel L. Horowitz   +3 more
openaire   +4 more sources

ANALYSIS OF PATH NONPARAMETRIC TRUNCATED SPLINE MAXIMUM CUBIC ORDER IN BANKING CREDIT OF RISK BEHAVIOR MODEL

Barekeng
Path analysis tests the relationship between variables through cause and effect. The assumption of linearity must be met before conducting further tests on path analysis. If the shape of the relationship is nonlinear and the shape of the curve is unknown,
Devi Veda Amanda, Atiek Iriany, Adji Achmad Rinaldo Fernandes, Solimun Solimun   +3 more
doaj   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

Local Polynomial Estimator in The Nonparametric Model of Inflation in Indonesia

Cauchy: Jurnal Matematika Murni dan Aplikasi
Inflation is a general and continuous increase in prices of goods and services over a certain period.  Nonparametric regression analysis can be used to model inflation data that does not form a particular pattern.
Abdul Aziz, Nur Chamidah, Toha Saifudin
doaj   +1 more source