Clinical Pharmacology &Therapeutics, EarlyView.Although patients with acute coronary syndrome supported by veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) have a high risk of thrombosis and bleeding, antiplatelet pharmacology in this setting is not well defined. This prospective observational study investigated the population pharmacokinetics of ticagrelor and its active metabolite AR ...
Soyoung Kang +9 more
wiley +1 more source
The impact of the 2019 revision of China's drug administration law on the innovative output of pharmaceutical and biotechnology enterprises-a quasi-natural experimental study using sharp regression discontinuity design. [PDF]
Front Med (Lausanne)Zhu Y, Liu Y, Chen Y, Meng L.
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Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Statistical inference for heterogeneous treatment effect with right-censored data from synthesizing randomized clinical trials and real-world data. [PDF]
BiometricsMao G, Yang S, Wang X.
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Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT Large companies have a long track record of environmental, social, and governance (ESG) initiatives, whereas many small and medium‐sized enterprises (SMEs) lag in adopting sustainability‐related practices, often acting voluntarily or in response to stakeholder pressures and incentives.
Vivien Csapi +4 more
wiley +1 more source
Perceived organisational support, psychological resilience and turnover intention among hospital nurses: mediation and network analyses. [PDF]
BMC NursDing J +8 more
europepmc +1 more source
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT This study aims to enhance academic understanding of the factors influencing the disclosure practices of climate change among European utility companies, specifically in the context of their sustainability reporting. The primary objective is to explore, through a multi‐theoretical framework, the governance drivers that significantly affect the
Cristina Boţa‐Avram +2 more
wiley +1 more source
Development of a risk prediction model for dialysis access steal syndrome: exploring the interaction and modifying role of BMI. [PDF]
Front Public HealthLiu Y, Huo Z, Gao X, Wang X.
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Rockburst prediction based on data preprocessing and hyperband‐RNN‐DNN
Deep Underground Science and Engineering, EarlyView.A data preprocessing workflow is proposed to address challenges in rockburst data analysis. Coupled algorithms preprocess the data set, and hyperband optimization is used to enhance RNN performance. Results show that preprocessing improves accuracy, while dense layers enhance model stability and prediction performance.
Yong Fan +4 more
wiley +1 more source
Potential of margin reduction for cervical cancer radiotherapy in an online adaptive image-guided workflow. [PDF]
Phys Imaging Radiat OncolLi F +9 more
europepmc +1 more source