Results 81 to 90 of about 25,247 (168)

Integration of Machine Learning With PBPK and QSAR Modeling Approaches to Facilitate Drug Discovery and Development

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 4, April 2026.
ABSTRACT This review examines the application of machine learning (ML) in physiologically based pharmacokinetic (PBPK) modeling through improved prediction of input parameters, particularly via quantitative structure–activity relationship (QSAR) models, for absorption, distribution, metabolism, and excretion (ADME) properties across drug development ...
Xinyue Chen, Zhoumeng Lin
wiley   +1 more source

A GIS‐Integrated Active Learning Framework for Crash Severity Classification in Imbalanced Traffic Data

open access: yesTransactions in GIS, Volume 30, Issue 2, April 2026.
ABSTRACT Classifying urban traffic crash severity remains challenging because severe incidents are underrepresented in highly imbalanced datasets. This challenge is further intensified by spatiotemporal shifts in data distributions, which can degrade model performance over time.
Reza Mohammadi, Mohammad Taleai
wiley   +1 more source

Commissioning and clinical implementation of an MLC tracking system: An evaluation of AAPM TG‐264 guidelines

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 3, March 2026.
Abstract Background Precise radiotherapy relies on accurately targeting tumours while minimising exposure to healthy tissue, yet patient and organ motion complicate treatment delivery. To address intra‐fractional motion, multi‐leaf collimator (MLC) tracking systems have recently been adopted, adapting beam shapes in real‐time.
André Haraldsson   +6 more
wiley   +1 more source

Proactive Environmental Strategy and Green Brand Positioning: Implications for Sustainable Development and Firm Performance in B2B Markets

open access: yesCorporate Social Responsibility and Environmental Management, Volume 33, Issue 2, Page 2887-2905, March 2026.
ABSTRACT This study investigates how proactive environmental strategy, operationalized through company environmental strategy (CES) and green marketing strategy (GMS), shapes green brand competitiveness (GBC) and new green product success (NGPS) via green brand positioning (GBP).
Haozhe Ma, Arnaldo Coelho, Célia Santos
wiley   +1 more source

Spatial Segregation and Trophic Niche Divergence in Two Disjunct Populations of Wedge‐Tailed Shearwater Ardenna pacifica in Eastern Australia

open access: yesEcology and Evolution, Volume 16, Issue 3, March 2026.
This study investigated habitat use and trophic niche differentiation in two wedge‐tailed shearwater populations in eastern Australia (2015 to 2019). Temperate birds foraged mainly in southeastern Australian waters and undertook a pre‐staging detour towards the subtropical frontal zone before migration, whereas subtropical birds foraged further east ...
Penny E. Beaver   +3 more
wiley   +1 more source

Somatosensory Evoked BOLD‐Signals With Ultra‐High Temporal Resolution

open access: yesHuman Brain Mapping, Volume 47, Issue 4, March 2026.
This study employed a novel combination of methodological approaches to examine the spatiotemporal dynamics of the somatosensory‐evoked BOLD signal across the whole brain with high temporal resolution (60 ms). By applying a time‐resolved hemodynamic analysis, this approach allows for inspection of 4D spatiotemporal dynamics of the BOLD signal ...
Sara Wesolek   +3 more
wiley   +1 more source

Establishment of Reference Intervals for Plasma TSH Across the Lifespan in an Algerian Mediterranean Population

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 6, March 2026.
This study establishes the first age‐specific reference intervals for plasma thyroid‐stimulating hormone (TSH) in an Algerian Mediterranean population using the Mindray CL‐900i platform. Analysis of 2893 healthy individuals revealed a strong age dependency of TSH values, with highest levels in neonates and mild elevation in older adults, while sex ...
Said Ali   +16 more
wiley   +1 more source

An Association Test for Ordinal Outcomes in Clustered Data With Informative Cluster Size

open access: yesPharmaceutical Statistics, Volume 25, Issue 2, March/April 2026.
ABSTRACT In cluster‐correlated data, the number of observations in a cluster can be associated with the outcome from that cluster. This phenomenon is known as informative cluster size which can occur in cluster‐randomized clinical trial data. Several studies have found that ignoring the issue of informative cluster size can produce biased results in ...
Hasika K. Wickrama Senevirathne   +1 more
wiley   +1 more source

Can Patient Education Lead the Way? Head‐To‐Head Comparison of EXACT and CERT for Early Recognition of Acute COPD Exacerbations

open access: yesRespirology, Volume 31, Issue 3, Page 256-264, March 2026.
Daily head‐to‐head comparison of EXACT vs. CERT for early detection of acute COPD exacerbations. Both tools accurately identified exacerbations at diagnosis (AUC≈0.9), but CERT detected worsening one day earlier (p = 0.006). CERT's simplicity and free access support rapid patient self‐monitoring and may enable timely intervention. See related editorial
Rainer Gloeckl   +9 more
wiley   +1 more source

Drought and Diversification‐Mediated Soil Legacies Influence Plant Growth and Rhizosheath Formation

open access: yesJournal of Sustainable Agriculture and Environment, Volume 5, Issue 1, March 2026.
ABSTRACT While drought legacy effects are widely reported, how distinct soil biological legacies created by diversification of crops through rotation influence plant performance remains largely untested. Moreover, it remains to be investigated whether crop domestication has impacted such biological legacy effects on plant performance.
Anuj Saraswat   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy