Results 251 to 260 of about 333,475 (312)

The impact of a preprescribing formative assessment on learning in final‐year medical students using hospital inpatient electronic prescribing systems

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Graduating medical students consistently report being unprepared for the complexity of prescribing in clinical practice. Current clinical prescribing teaching and authentic assessment are limited due to patient safety concerns. We aimed to examine the educational utility of supervised preprescribing as a learning process and potential authentic ...
Kellie A. Charles   +7 more
wiley   +1 more source

A real‐world data‐driven approach to optimizing enoxaparin dosing in burn patients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Enoxaparin dosing in burn patients is challenging due to physiological changes affecting absorption, distribution and clearance. The objectives of this study are to develop a population pharmacokinetic (PK) model for enoxaparin in burn patients, evaluate target attainment with current equation‐based (EQ) dosing and propose an optimized dosing ...
Babajide Shenkoya   +3 more
wiley   +1 more source

N‐of‐1 trials in clinical research: Methodological foundations, statistical approaches and implementation challenges

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
N‐of‐1 trials offer a unique and rigorous methodology for evaluating individualized treatment responses, particularly within the context of personalized medicine. This article provides a comprehensive explanation of the conceptual and methodological underpinnings of N‐of‐1 trials, with particular emphasis on statistical techniques and considerations ...
Marcos Clint Leal De Carvalho   +5 more
wiley   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet   +17 more
wiley   +1 more source

A Guide to Bayesian Optimization in Bioprocess Engineering

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Bayesian optimization has become widely popular across various experimental sciences due to its favorable attributes: it can handle noisy data, perform well with relatively small data sets, and provide adaptive suggestions for sequential experimentation.
Maximilian Siska   +5 more
wiley   +1 more source

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