Results 11 to 20 of about 10,805 (226)

Managing Drug-Drug Interactions Involving the Non-Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Loperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and intestinal efflux by P‐glycoprotein (P‐gp).
Zhou Z, Ainslie GR, Li M, Dinh J, Zamek-Gliszczynski MJ, Zhao P, Paine MF.   +6 more
europepmc   +2 more sources

Combination vs. single-drug nonprescription analgesics for acute pain management: A narrative review. [PDF]

Br J Clin Pharmacol
Combining nonprescription analgesics with different mechanisms of action has been proposed as a rational strategy to optimize the management of acute pain. This review assessed the efficacy and safety of nonprescription analgesics, including paracetamol (acetaminophen), metamizole and nonsteroidal anti‐inflammatory drugs (NSAIDs) used in combination vs.
Mobasheri A, Morlion B, Sethi VS, Cardosa M, Della Pasqua O, Kalita P.   +5 more
europepmc   +2 more sources

Long-Term Impact of EGUIDE Training on Facility-Wide Guideline Adherence Rate in Schizophrenia and Major Depressive Disorder: A Multicenter Study. [PDF]

Neuropsychopharmacol Rep
EGUIDE training produced sustained facility‐wide improvements in schizophrenia guideline adherence over seven years. Seven of eleven quality indicators significantly improved, including treatment‐resistant schizophrenia assessment and modified electroconvulsive therapy use, suggesting knowledge spillover effects from trained to nonparticipating ...
Hasegawa N, Muraoka H, Arai Y, Horinouchi T, Yamamuro K, Hashimoto N, Ochi S, Tsuboi T, Kawamata Y, Nakamura T, Yasuda Y, Matsumoto J, Ito S, Onitsuka T, Ohi K, Numata S, Hori H, Inada K, Watanabe K, Yasui-Furukori N, Hashimoto R.   +20 more
europepmc   +2 more sources

The utilization of nonprescription medications in Saudi patients with cardiovascular diseases

Saudi Pharmaceutical Journal, 2018
Background: Cardiovascular diseases (CVDs) are the most common cause of disease-related death in Saudi Arabia. The incidence of CVDs continues to increase, presenting a major health care problem.
Eman M. Shorog, Khalid A. Alburikan
doaj   +1 more source

Bilateral nephrolithiasis following ingestion of guaifenesin and dextromethorphan

Urology Case Reports, 2023
Both guaifenesin and dextromethorphan are routinely available nonprescription medications that are also common drugs of abuse amongst young adults. We describe a presentation of guaifenesin and dextromethorphan misuse resulting in acute renal failure due
Elizabeth Kim, Michael Perlmutter, Haley Zweber, Joseph Resch   +3 more
doaj   +1 more source

Consumption of Non-Prescribed Drugs in Portugal During the Pandemic in 2021

International Journal of Public Health, 2023
Objectives: Portugal liberalised the over-the-counter drugs market in 2005 and provides universal healthcare coverage in a mainly Beveridge-type health system.
Aida Isabel Tavares, Aida Isabel Tavares, Pedro Lopes Ferreira, Pedro Lopes Ferreira, Vitor Raposo, Vitor Raposo, Vitor Raposo, Carlota Quintal, Carlota Quintal, Carlota Quintal   +9 more
doaj   +1 more source

Evaluation of a pharmacist-led medication assessment used to identify prevalence of and associations with polypharmacy and potentially inappropriate medication use among ambulatory senior adults with cancer. [PDF]

, 2015
PURPOSE: The use of multiple and/or inappropriate medications in seniors is a significant public health problem, and cancer treatment escalates its prevalence and complexity.
Andrel-Sendecki, Jocelyn, Chapman, Andrew, Hajjar, Emily, Nightingale, Ginah, Swartz, Kristine   +4 more
core   +2 more sources

Evaluation of Point-of-Care Resources for Dietary Supplement Information

Journal of Evidence-Based Integrative Medicine, 2018
Objective. To evaluate 6 tertiary, point-of-care drug information resources’ dietary supplement content. Methods. This was a cross-sectional evaluation of Lexicomp Natural Products Database, Micromedex Alternative Medicine, Clinical Pharmacology, Natural
Ashley E. Montgomery PharmD, Robert D. Beckett PharmD, BCPS, Kaitlin J. Montagano, Samah Kutom   +3 more
doaj   +1 more source

Role of community pharmacy and pharmacists in self-care in Brazil

Exploratory Research in Clinical and Social Pharmacy, 2023
Global healthcare systems, including the National Health System in Brazil – one of the largest public models in the world –, continue to evolve, as well as populations' health needs, currently shaped on individuals feeling a greater desire to manage ...
Inajara Rotta, Tácio Lima, Fernanda S. Tonin   +2 more
doaj   +1 more source

Structured frameworks to increase the transparency of the assessment of benefits and risks of medicines: current status and possible future directions [PDF]

, 2015
Structured frameworks for benefit-risk analysis in drug licensing decisions are being implemented across a number of regulatory agencies worldwide.
Ashby, D, Brass, EP, Eichler, H-G, Frey, P, Hillege, HL, Hori, A, Levitan, B, Liberti, L, Loefstedt, RE, McAuslane, N, Micaleff, A, Noel, RA, Pignatti, F, Postmus, D, Renn, O, Sabourin, BJ, Salmonson, T, Walker, S   +17 more
core   +2 more sources