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Trends in Cell Biology, 2008
To ensure the accuracy of gene expression, eukaryotes have evolved several surveillance mechanisms. One of the best-studied quality control mechanisms is nonsense-mediated mRNA decay (NMD), which recognizes and degrades transcripts harboring a premature translation-termination codon (PTC), thereby preventing the production of faulty proteins.
Stalder, Lukas, Mühlemann, Oliver
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To ensure the accuracy of gene expression, eukaryotes have evolved several surveillance mechanisms. One of the best-studied quality control mechanisms is nonsense-mediated mRNA decay (NMD), which recognizes and degrades transcripts harboring a premature translation-termination codon (PTC), thereby preventing the production of faulty proteins.
Stalder, Lukas, Mühlemann, Oliver
openaire +4 more sources
Proceedings of the 6th ACM SIGPLAN International Workshop on Functional Art, Music, Modeling, and Design, 2018
The notion of effect in programming languages has evolved significantly since the works of Lucassen and Gifford – where an effect system tracks memory regions and enables the improvement of parallel execution – to the point where an algebraic characterisation of effects is proposed. In this work, we seize the such notions to design a calculus, λgenArt,
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The notion of effect in programming languages has evolved significantly since the works of Lucassen and Gifford – where an effect system tracks memory regions and enables the improvement of parallel execution – to the point where an algebraic characterisation of effects is proposed. In this work, we seize the such notions to design a calculus, λgenArt,
openaire +2 more sources
Archives of Pediatrics & Adolescent Medicine, 1973
To the Editor. —Thanks to physicians' voracious intellectual appetite for medical research and writing, the main pediatric publications—unlike Life —are still alive, in the face of dwindling support for research. They are alive, but not well. Quality of the contents has deteriorated. This is clearly not due to a dearth of contributions.
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To the Editor. —Thanks to physicians' voracious intellectual appetite for medical research and writing, the main pediatric publications—unlike Life —are still alive, in the face of dwindling support for research. They are alive, but not well. Quality of the contents has deteriorated. This is clearly not due to a dearth of contributions.
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Is There No Sense in Nonsense? Co-tranforming the Apparently Nonsensical
2017In the throes of … nothingness, a person may feel anguish. He [sic!] feels as though he were drowning in non-sense and nothing can save him. All his efforts seemed to have failed, and he shouts for life. Does his intense pain mean anything? Will anything make sense? Does nothing make sense? (Kraft 1974, 21).
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Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes
Molecular Cell, 2023Hironori Adachi +2 more
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