Results 291 to 300 of about 412,807 (382)

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Genetic purging in an island-endemic pigeon recovering from the brink of extinction. [PDF]

Commun Biol
Tsujimoto D, Takayanagi M, Ishii J, Sakashita R, Horikoshi K, Suzuki H, Isagi Y.   +6 more
europepmc   +1 more source

Non-radiate flowers are associated with truncation of the CYCLOIDEA gene in Scaevola aemula (Goodeniaceae). [PDF]

Sci Rep
Tomomatsu K, Tsuji T, Segawa T, Ono E, Koyama T, Morimoto T, Bernuetz A, Suzuki K, Matsui K, Itai A.   +9 more
europepmc   +1 more source

The Electronic Spin State of Diradicals Obtained from the Nuclear Perspective: The Strange Case of Chichibabin Radicals

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
The electronic spin state of two Chichibabin radicals is investigated using 2‐dimensional hyperfine correlated Electron Nuclear Double Resonance. The protons (I=1/2) act as a reference for the electronic spin quantum number (S) via their hyperfine interactions.
Gabriel Moise, Saleta Fernández, Kit Joll, Mikhail V. Vaganov, Fátima García, Christiane R. Timmel, Diego Peña, Arzhang Ardavan   +7 more
wiley   +1 more source

Glycine <i>N</i>-Acyltransferase Deficiency due to a Homozygous Nonsense Variant in the <i>GLYAT</i>: A Novel Inborn Error of Metabolism. [PDF]

JIMD Rep
Nourbakhsh M, Miryounesi M, Tale A, Karimzadeh P, Sadeghi H, Ghasemi MR, Alipour N, Pourbakhtyaran E, Hooman N, Razzaghy-Azar M, Nourbakhsh M, Klaas L, Schulke D, Sass JO.   +13 more
europepmc   +1 more source

Mediation Agreement in the Courtroom

Conflict Resolution Quarterly, EarlyView.
ABSTRACT Existing European legal scholarship focuses primarily on legal frameworks and conditions for mediation, while not delving into practical aspects of mediation on the ground. Concurrently, the social sciences lack the analysis of roles and approaches of different actors in mediation.
Lenka Dušková, Jan Holas
wiley   +1 more source

Development of translational read-through-inducing drugs as novel therapeutic options for patients with Fanconi anemia. [PDF]

Cell Death Discov
Hristodor AM, Cappelli E, Baldisseri E, Valli R, Montalbano G, Micheloni G, Porta G, Frattini A, Ravera S, Fioredda F, Lippi G, Dufour C, Cipolli M, Bezzerri V.   +13 more
europepmc   +1 more source

The UK National Youth Work Curriculum—Democratic challenges from Finland

The Curriculum Journal, EarlyView.
Abstract This article compares the only two countries—the UK and Finland—that have systematically applied the concept of curriculum to youth work on the national level. It begins by charting the development of a curriculum in youth work in England which has culminated in the production of the new UK government's Department for Culture Media & Sport ...
Tomi Kiilakoski, Jon Ord
wiley   +1 more source

Comprehensive analysis of clinical phenotype and genetic characteristics of retinoblastoma caused by <i>RB1</i> gene mutation: a case series. [PDF]

Am J Cancer Res
Fu Z, Liu Y, Yang H, Xiong W, Yin X, Fang W, Li X, Wei X, Hu J.   +8 more
europepmc   +1 more source

Exon 44 nonsense mutation in two-duchenne muscular dystrophy brothers detected by heteroduplex analysis

, 1993
Thomas W. Prior, Audrey C. Papp, Pamela J. Snyder, Arthur H.M. Burghes, Mary S. Sedra, Lorraine M. Western, Claire Bartolo, Jerry R. Mendell   +7 more
openalex   +1 more source