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ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis. [PDF]
Ko W+11 more
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Dynamic changes of chronic hepatitis B patient with loss of surface antigen: a case report. [PDF]
Wang C, Lin L, Ding DP.
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Trends in Cell Biology, 2008
To ensure the accuracy of gene expression, eukaryotes have evolved several surveillance mechanisms. One of the best-studied quality control mechanisms is nonsense-mediated mRNA decay (NMD), which recognizes and degrades transcripts harboring a premature translation-termination codon (PTC), thereby preventing the production of faulty proteins.
Lukas Stalder, Oliver Mühlemann
openaire +3 more sources
To ensure the accuracy of gene expression, eukaryotes have evolved several surveillance mechanisms. One of the best-studied quality control mechanisms is nonsense-mediated mRNA decay (NMD), which recognizes and degrades transcripts harboring a premature translation-termination codon (PTC), thereby preventing the production of faulty proteins.
Lukas Stalder, Oliver Mühlemann
openaire +3 more sources
Wiley Interdisciplinary Reviews - RNA, 2019
Nonsense‐mediated RNA decay (NMD) is an evolutionarily conserved RNA quality control process that serves both as a mechanism to eliminate aberrant transcripts carrying premature stop codons, and to regulate expression of some normal transcripts.
Michael C. Dyle+3 more
semanticscholar +1 more source
Nonsense‐mediated RNA decay (NMD) is an evolutionarily conserved RNA quality control process that serves both as a mechanism to eliminate aberrant transcripts carrying premature stop codons, and to regulate expression of some normal transcripts.
Michael C. Dyle+3 more
semanticscholar +1 more source
Archives of Pediatrics & Adolescent Medicine, 1973
To the Editor. —Thanks to physicians' voracious intellectual appetite for medical research and writing, the main pediatric publications—unlike Life —are still alive, in the face of dwindling support for research. They are alive, but not well. Quality of the contents has deteriorated. This is clearly not due to a dearth of contributions.
openaire +3 more sources
To the Editor. —Thanks to physicians' voracious intellectual appetite for medical research and writing, the main pediatric publications—unlike Life —are still alive, in the face of dwindling support for research. They are alive, but not well. Quality of the contents has deteriorated. This is clearly not due to a dearth of contributions.
openaire +3 more sources
Nonsense Mediated RNA Decay Pathway Inhibition Restores Expression and Function of W1282X CFTR.
American Journal of Respiratory Cell and Molecular Biology, 2019RATIONALE The recessive genetic disease cystic fibrosis is caused by loss of function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Approximately 10% of cystic fibrosis patients have at least one allele with a nonsense
M. Keenan+11 more
semanticscholar +1 more source