Results 11 to 20 of about 20,553 (236)
Nonsense suppression in archaea [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Three stop codons are used as translation termination signals within the mRNA. Nonsense suppression is defined as the read through of stop codons in an mRNA by a class of mutant tRNAs called nonsense suppressor tRNAs. Although much is known about nonsense suppression in bacteria (e.g.,
Debabrata Mandal +2 more
exaly +7 more sources
Nonsense suppression therapies in ocular genetic diseases [PDF]
Cellular and Molecular Life Sciences, 2015 Premature termination codons (PTCs) are caused by nonsense mutations and this leads to either degradation of the mutant mRNA template by nonsense-mediated decay (NMD) or the production of a non-functional, truncated polypeptide. PTCs contribute significantly to inherited human diseases including ocular disorders.
Cheryl Y Gregory-Evans, Xia Wang
exaly +4 more sources
Nonsense mRNA suppression via nonstop decay
eLife, 2018 Nonsense-mediated mRNA decay is the process by which mRNAs bearing premature stop codons are recognized and cleared from the cell. While considerable information has accumulated regarding recognition of the premature stop codon, less is known about the ...
Joshua A Arribere, Andrew Z Fire
doaj +5 more sources
Nonsense suppression therapies in human genetic diseases. [PDF]
Cell Mol Life Sci, 2021 About 11% of all human disease-associated gene lesions are nonsense mutations, resulting in the introduction of an in-frame premature translation-termination codon (PTC) into the protein-coding gene sequence. When translated, PTC-containing mRNAs originate truncated and often dysfunctional proteins that might be non-functional or have gain-of-function ...
Martins-Dias P, Romão L.
europepmc +3 more sources
Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Steven M Rowe +2 more
exaly +2 more sources
Ataluren as an agent for therapeutic nonsense suppression. [PDF]
Annu Rev Med, 2013 The interplay of translation and mRNA turnover has helped unveil how the regulation of gene expression is a continuum in which events that occur during the birth of a transcript in the nucleus can have profound effects on subsequent steps in the cytoplasm.
Peltz SW, Morsy M, Welch EM, Jacobson A.
europepmc +4 more sources
Inducing nonsense suppression by targeted pseudouridylation. [PDF]
Nat Protoc, 2012 Isomerization from uridine to pseudouridine (pseudouridylation) is largely catalyzed by a family of small ribonucleoproteins called box H/ACA RNPs, each of which contains one unique small RNA-the box H/ACA RNA. The specificity of the pseudouridylation reaction is determined by the base-pairing interactions between the guide sequence of the box H/ACA ...
Huang C, Wu G, Yu YT.
europepmc +4 more sources
StopKB: a comprehensive knowledgebase for nonsense suppression therapies. [PDF]
Database (Oxford)Abstract Nonsense variations, characterized by premature termination codons, play a major role in human genetic diseases as well as in cancer susceptibility. Despite their high prevalence, effective therapeutic strategies targeting premature termination codons remain a challenge.
Haas N +4 more
europepmc +5 more sources
Long-term nonsense suppression therapy moderates MPS I-H disease progression [PDF]
Molecular Genetics and Metabolism, 2014 Trenton R Schoeb +2 more
exaly +2 more sources
Molecular Therapy: Nucleic Acids, 2023 Neurofibromatosis type 1 (NF1) results from germline mutations in the tumor-suppressor gene NF1 and predisposes patients to developing nervous system tumors.
Sara H. Osum +12 more
doaj +1 more source