Results 141 to 150 of about 56,005 (221)

Membrane Topology of Pestiviral Non-Structural Protein 2 and determination of the minimal autoprotease domain. [PDF]

J Virol, 2021
Walther T, Fellenberg J, Klemens O, Isken O, Tautz N.   +4 more
europepmc   +1 more source

Determine the frequency distribution of hepatocellular carcinoma (HCC) and evaluation of viral persistence in the development of HCC among Pakistani patients

Journal of the Pakistan Medical Association
Objective: To determine the frequency distribution of hepatocellular carcinoma, and to evaluate viral persistence and its association with viral titers.
Saleha Resham , Moomal khan, Eeman Rahman , Fazal Adnan, Sobia Manzoor   +4 more
doaj   +1 more source

The full-length nsp2 replicase contributes to viral assembly in highly pathogenic PRRSV-2

Journal of Virology
Porcine reproductive and respiratory syndrome viruses (PRRSVs) are significant pathogens that affect the global swine industry. Its virions consist of a central core composed of nucleocapsid (N) protein, surrounded by multiple distinct viral envelope ...
Yuan-Zhe Bai, Shujie Wang, Yue Sun, Yong-Gang Liu, Hong-Liang Zhang, Qian Wang, Rui Huang, Cui-Hong Rao, Shi-Jia Xu, Zhi-Jun Tian, Tong-Qing An, Xue-Hui Cai, Yan-Dong Tang   +12 more
doaj   +1 more source

Brown Mid-Rib Corn Variety Trial [PDF]

, 2013
Brown mid-rib (BMR) corn has a lower lignin content than other silage corn varieties. The lower lignin content increases the fiber digestibility (NDF digestibility) of the corn silage. Increases in NDF digestibility lead to increased in dry matter intake,
Burke, Conner, Cummings, Erica, Darby, Heather, Harwood, Hannah, Madden, Laura, Monahan, Susan   +5 more
core   +2 more sources

Assay development and screening of inhibitors targeting the SARS-CoV-2 2′-O-methyltransferase NSP16

Pharmaceutical Science Advances
The coronavirus disease-2019 (COVID-19) pandemic, etiologically caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has profoundly impacted the global health.
Mengtong Cao, Carl W. Trieshmann, Subodh Kumar Samrat, Hongmin Li, Yifei Wu, Steven P. Maher, Angela A. Bae, Zhong-Ru Xie, Robert J. Hogan, Y. George Zheng   +9 more
doaj   +1 more source

Small Grain Forage Trial Nitrogen Fertility and Harvest Date [PDF]

, 2012
Cool season annual forages, such as cereal grains, can provide early season grazing as well as high quality stored feed. However, it is unclear if quality and yield of these forages could be improved through better fertility management.
Cummings, Erica, Darby, Heather, Harwood, Hannah, Madden, Rosalie, Monahan, Susan   +4 more
core   +1 more source

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors

Journal of the American Chemical Society
The COVID-19 pandemic, exacerbated by persistent viral mutations, underscored the urgent need for diverse inhibitors targeting multiple viral proteins. In this study, we utilized covalent DNA-encoded libraries to discover innovative triazine-based covalent inhibitors for the 3-chymotrypsin-like protease (3CLpro, Nsp5) and the papain-like protease ...
Xudong Wang, Liwei Xiong, Ying Zhu, Sixiu Liu, Wenfeng Zhao, Xinyuan Wu, Mengnisa Seydimemet, Linjie Li, Peiqi Ding, Xian Lin, Jiaxiang Liu, Xuan Wang, Zhiqiang Duan, Weiwei Lu, Yanrui Suo, Mengqing Cui, Jinfeng Yue, Rui Jin, Mingyue Zheng, Yechun Xu, Lianghe Mei, Hangchen Hu, Xiaojie Lu   +22 more
openaire   +2 more sources

SARS-CoV-2 Nsp15 endoribonuclease subverts host defenses to enhance viral fitness in lung cells

Journal of Virology
Coronaviruses encode nonstructural protein 15 (Nsp15), a conserved endoribonuclease (EndoU) known to suppress host antiviral responses. It is imperative to understand the role of Nsp15/EndoU during severe acute respiratory syndrome coronavirus 2 (SARS ...
Xiang Chi, Xueying Liang, Kishore Vaddadi, Xiaoming Zhang, Chaitanya Gandikota, Sunil More, Lin Liu, Xufang Deng   +7 more
doaj   +1 more source

Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions [PDF]

, 1985
We have obtained a vaccinia virus recombinant which contains a complete cDNA copy of the 26S RNA of Sindbis virus within the thymidine kinase gene of the vaccinia virus genome.
Franke, Christine A., Hruby, Dennis E., Rice, Charles M., Strauss, James H.   +3 more
core  

Vinyl Sulfone-Based Inhibitors of Nonstructural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus. [PDF]

ACS Med Chem Lett, 2020
Zhang H, Harmon M, Radoshitzky SR, Soloveva V, Kane CD, Duplantier AJ, Ogungbe IV.   +6 more
europepmc   +1 more source