Results 191 to 200 of about 56,005 (221)

Nanodelivery system enhances the immunogenicity of dengue-2 nonstructural protein 1, DENV-2 NS1

Vaccine, 2020
Nonstructural protein 1 (NS1) of dengue virus (DENV) is currently recognized as a dengue vaccine candidate. Unfortunately, most of non-replicating immunogens typically stimulate unsatisfactory immune responses, thus, the additional adjuvant is required.
Tuksin, Jearanaiwitayakul, Panya, Sunintaboon, Runglawan, Chawengkittikul, Jitra, Limthongkul, Panuwat, Midoeng, Saradee, Warit, Sukathida, Ubol   +6 more
openaire   +2 more sources

Rubella virus nonstructural protein 2 is a minor immunogen

Virus Research, 2000
The full-length nonstructural protein P90 of rubella virus (RV) was expressed as recombinant protein in Escherichia coli bacteria, as well as in Vero cells. Monoclonal antibodies raised against the protein specifically reacted with the protein in both P90-transfected and RV infected Vero cells. Ninety human sera obtained from reconvalescents, vaccinees
J, Hofmann, S, Gerstenberger, I, Lachmann, C D, Atreya, U G, Liebert   +4 more
openaire   +2 more sources

SARS-CoV-2 type I Interferon modulation by nonstructural proteins 1 and 2

2022
AbstractSince the beginning of the COVID-19 pandemic, enormous efforts were devoted to understanding how SARS-CoV-2 escapes the antiviral response. Yet, modulation of type I interferons (IFNs) by this virus is not completely understood. Using in vitro and in vivo approaches, we have characterized the type I IFN response during SARS-CoV-2 infection as ...
Émile Lacasse, Isabelle Dubuc, Leslie Gudimard, Annie Gravel, Isabelle Allaeys, Éric Boilard, Louis Flamand   +6 more
openaire   +1 more source

Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2

Journal of Virology, 1994
We determined the partial amino (N)-terminal amino acid sequence of hepatitis C virus p21 (nonstructural protein 2 [NS2]). Cleavage at the p21 (NS2) N terminus depended on the presence of microsomal membranes. The amino-terminal position of p21 (NS2) was assigned to amino acid 810 of the hepatitis C virus strain IIJ precursor polyprotein.
H, Mizushima, M, Hijikata, Y, Tanji, K, Kimura, K, Shimotohno   +4 more
openaire   +2 more sources

Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A #

Hepatology, 2009
Abstract Numerous anti-hepatitis C virus (HCV) drugs targeting either the viral nonstructural 3 (NS3) protease or NS5B polymerase are currently in clinical testing. However, rapid resistance development is a major problem and optimal therapy will clearly require a combination of multiple mechanisms of action.
Sandra, Ciesek, Eike, Steinmann, Heiner, Wedemeyer, Michael P, Manns, Johann, Neyts, Norbert, Tautz, Vanesa, Madan, Ralf, Bartenschlager, Thomas, von Hahn, Thomas, Pietschmann   +9 more
openaire   +2 more sources

Chapter 2 New Insights into Flavivirus Nonstructural Protein 5

2009
Disease caused by flavivirus infections is an increasing world health problem. Flavivirus nonstructural protein 5 (NS5) possesses enzymatic activities required for capping and synthesis of the viral RNA genome and is essential for virus replication. NS5 is comprised of two domains.
openaire   +2 more sources

Proteolytic processing of the nonstructural proteins of dengue 2 virus

1990
The genomes of many positive stranded RNA viruses and of all retroviruses are translated as large polyproteins which are proteolytically processed by cellular and viral proteases. Viral proteases are structurally related to two families of cellular proteases, the pepsin-like and trypsin-like proteases.
openaire   +1 more source

Macrodomain Mac1 of SARS-CoV-2 Nonstructural Protein 3 Hydrolyzes Diverse ADP-ribosylated Substrates

2023
ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic that resulted in more than 6-million deaths worldwide. The virus encodes several non-structural proteins (Nsps) that contain elements capable of disrupting cellular processes.
Chanbora, Chea, Duck-Yeon, Lee, Jiro, Kato, Hiroko, Ishiwata-Endo, Joel, Moss   +4 more
openaire   +2 more sources

Nonstructural proteins of SARS-CoV-2

Journal of Allergy & Infectious Diseases, 2021
Jason Y Tang, Igor F. Tsigelny, Valentina L. Kouznetsova   +2 more
openaire   +1 more source

Mutations in nonstructural proteins essential for pathogenicity in SARS-CoV-2-infected mice

Journal of Virology
ABSTRACT Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has resulted in substantial morbidity and mortality. The basis of severe disease in humans is difficult to determine without the use of experimental animal models.
Ruangang Pan, Pengfei Li, David K. Meyerholz, Stanley Perlman   +3 more
openaire   +2 more sources