Results 271 to 280 of about 255,180 (315)

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Strategies for discontinuing vasopressin and norepinephrine during the recovery phase of shock: a single-center retrospective study. [PDF]

J Intensive Care
Suganuma S, Uchino S, Nishiyama S, Sasabuchi Y, Katayama S.   +4 more
europepmc   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Vasopressin Initiation Timing and In-Hospital Mortality in Septic Shock: An Observational Study of Large Public Databases. [PDF]

Crit Care Explor
Sacha GL, Duggal A, Reddy AJ, Wang L, Bauer SR.   +4 more
europepmc   +1 more source

The real‐world relationship between naltrexone/bupropion treatment and weight loss in Canada: A retrospective chart review

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary This study examined the change in weight at 6 months of naltrexone/bupropion (NB), a combination pharmacological therapy for weight management, in real‐world practice in Canada. The study was conducted through an observational, retrospective, single‐arm chart review of adult patients who attended the Wharton Medical Clinic in Ontario, Canada ...
Sean Wharton, Elham Kamran, Lehana Thabane, Peter Yin, Rebecca Christensen   +4 more
wiley   +1 more source

Basic Science and Pathogenesis. [PDF]

Alzheimers Dement
Tish MM, Gao L, Ou Z, Weinshenker D, Birey F.   +4 more
europepmc   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Intravenous lidocaine reduces pain intensity and attenuates the increase in plasma norepinephrine levels after hysterectomy. [PDF]

Qatar Med J
Musba AMT, Sardi S, Ratnawati.
europepmc   +1 more source

ChronoSynthNet: a dual-task deep learning model development and validation study for predicting real-time norepinephrine dosage and the early detection of hypotension in patients with septic shock. [PDF]

Cardiovasc Diagn Ther
Jiang Z, Zhang S, Yuan Y, Wang J, Hu Z.
europepmc   +1 more source

Hemodynamic and microcirculatory early adaptations following transcatheter aortic valve implantation (TAVI): A physiological pilot study

European Journal of Clinical Investigation, EarlyView.
This pilot physiological study, involving 20 patients with severe aortic stenosis, shows that transcatheter aortic valve implantation (TAVI) induces rapid changes in both macrocirculatory parameters, reflecting the release of chronic obstruction. We observed improved tissue perfusion by postoperative Day 1, independent of macrocirculatory parameters ...
Stanislas Abrard, Sarah Mauler, Ivo Neto Silva, Dyonisios Adamopoulos, Stéphane Bar, Andres Hagerman, Raoul Schorer, Bernardo Bollen Pinto, Georgios Rovas, Nikolaos Stergiopulos, Christoph Ellenberger, Stéphane Noble, Karim Bendjelid   +12 more
wiley   +1 more source