Results 281 to 290 of about 131,387 (308)
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Angiotensin and norepinephrine efflux
European Journal of Pharmacology, 1969Abstract Rabbit aortae were equilibrated with labelled norepinephrine and the effects of various drugs on efflux of the catecholamine studied. Angiotensin amide (10 μg/ml) given at a rate of 0.18 ml/min increased norepinephrine efflux. Tyramine (100 μg/ml), cocaine (50 μg/ml), guanethidine (250 μg/ml), 0.25 and 0.4 M KCl, and acetylcholine (1 mg/ml ...
Philip A. Khairallah, Burhan K. Kiran
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Plasma Levels of Norepinephrine
Annals of Internal Medicine, 1978Plasma norepinephrine derives from sympathetic nerves, but the proportion reaching the circulation before being metabolized varies with the type of nerve ending-effector junctions in the tissue. Plasma levels of norepinephrine also will fluctuate because of rapid metabolism rates and environmental, emotional, and endogenous stimuli provoking a ...
Raymond C. Lake +2 more
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Origin of Norepinephrine in the Heart
Nature, 1963NOREPINEPHRINE is present in various organs of the body and in the blood plasma1. The adrenal medulla is not necessary for the maintenance of tissue stores of this catecholamine1, and it is likely that synthesis of norepinephrine occurs in the sympathetic nervous tissue throughout the body.
Irwin J. Kopin, Edna K. Gordon
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Norepinephrine in cerebrospinal fluid
Brain Research, 1976In peripheral tissues, noradrenergic nerves have a diffuse distribution, but in the brain, noradrenergic neurons arise in the brainstem and are inhomoge-neously distributed. The locus coeruleus is the largest noradrenergic nucleus in rat brain, and it contains only about 1500 neurons. Although norepinephrine is present in the brain in small amounts, it
Irwin J. Kopin +4 more
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Regulation of norepinephrine synthesis
Advances in Enzyme Regulation, 1971Summary The enzymes involved in the biosynthesis of norepinephrine, the chemical transmitter of the sympathetic nervous system, have now been characterized sufficiently so as to permit investigations on regulatory factors. It has become apparent that synthesis as well as release of the transmitter varies according to environmental factors. Changes in
Wallace Dairman, Sidney Udenfriend
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Regulation of Norepinephrine Biosynthesis
Annual Review of Pharmacology, 1970In addition to its ability to release norepinephrine consequent to stimula tion, the adrenergic neuron can carry out a variety of functions related to the metabolism of its neurotransmitter. Both the adrenal medulla chromaffin cells (1-3) and the adrenergic neuron (3-5) store norepinephrine within vesicles which exhibit a characteristic dense core as ...
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Serotonin, Norepinephrine, and Fever
1968Publisher Summary This chapter presents an association between brain monoamines and febrile responses in animals. It has been found that endotoxin fever is associated with an increase in brain 5-HT in the presence of phenylisopropylhydrazine (JB-516, an monoamine oxidase (MAO) inhibitor) and that MAO inhibition potentiates the febrile response to ...
C. Tanaka +3 more
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Annals of Pharmacotherapy, 2019
Background: The optimal adjuvant vasopressor to norepinephrine in septic shock remains controversial. Objective: To compare durations of shock-free survival between adjuvant vasopressin and epinephrine. Methods: A retrospective, single-center, matched cohort study of adults with septic shock refractory to norepinephrine was conducted.
Bryan E. Menich +3 more
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Background: The optimal adjuvant vasopressor to norepinephrine in septic shock remains controversial. Objective: To compare durations of shock-free survival between adjuvant vasopressin and epinephrine. Methods: A retrospective, single-center, matched cohort study of adults with septic shock refractory to norepinephrine was conducted.
Bryan E. Menich +3 more
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The Journal of Pharmacology and Experimental Therapeutics, 2000
Nitric oxide has been shown to react under physiologic conditions with norepinephrine (NE) to produce 6-nitro-norepinephrine (6-NO(2)-NE), a compound that enhances NE release in the brain. Previous studies suggest that 6-NO(2)-NE is formed in the spinal cord and stimulates spinal NE release to produce analgesia.
X, Li +5 more
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Nitric oxide has been shown to react under physiologic conditions with norepinephrine (NE) to produce 6-nitro-norepinephrine (6-NO(2)-NE), a compound that enhances NE release in the brain. Previous studies suggest that 6-NO(2)-NE is formed in the spinal cord and stimulates spinal NE release to produce analgesia.
X, Li +5 more
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Norepinephrine and the dentate gyrus
2007Norepinephrine's role in the dentate gyrus is assessed based on a review of what is known about its innervation and receptor patterns and its functional effects at both cellular and behavioral levels. The data support seven hypotheses: (1) Norepinephrine's functional actions are primarily mediated by beta adrenoceptors and include electrophysiological ...
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