Results 1 to 10 of about 28,537 (146)

Overview of the structure and function of the dopamine transporter and its protein interactions

Frontiers in Physiology, 2023
The dopamine transporter (DAT) plays an integral role in dopamine neurotransmission through the clearance of dopamine from the extracellular space. Dysregulation of DAT is central to the pathophysiology of numerous neuropsychiatric disorders and as such ...
Binod Nepal, Sanjay Das, Maarten E. Reith, Sandhya Kortagere   +3 more
doaj   +1 more source

Altered neurocircuitry in the dopamine transporter knockout mouse brain. [PDF]

PLoS ONE, 2010
The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters.
Xiaowei Zhang, Elaine L Bearer, Benoit Boulat, F Scott Hall, George R Uhl, Russell E Jacobs   +5 more
doaj   +1 more source

Effects of Extended-Release Methylphenidate on Dopamine and Norepinephrine Transporters in Adults With Attention-Deficit/Hyperactivity Disorder: A Longitudinal Dual-Tracer PET Study. [PDF]

Psychiatry Clin Neurosci
Aim Attention‐deficit/hyperactivity disorder (ADHD) is associated with dysregulation of dopamine and norepinephrine neurotransmission. Extended‐release methylphenidate (MPH), a first‐line treatment for ADHD, modulates these systems. However, its specific effects on the dopamine transporter (DAT) and norepinephrine transporter (NET) are inadequately ...
Oya M, Matsuoka K, Kubota M, Kitamura S, Kataoka Y, Kokubo N, Takahata K, Seki C, Endo H, Tagai K, Takado Y, Hirata K, Ichihashi M, Kurose S, Kato N, Sugihara G, Shimizu M, Takagi S, Ito W, Nakamura M, Higuchi M, Takahashi H.   +21 more
europepmc   +2 more sources

Subcellular localization of the antidepressant-sensitive norepinephrine transporter

BMC Neuroscience, 2009
Background Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis.
Winder Danny G, Moore Jessica L, Wright Jane, Shields Angela, Han Qiao, Matthies Heinrich JG, Galli Aurelio, Blakely Randy D   +7 more
doaj   +1 more source

Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences. [PDF]

J Biol Chem
Kastner N, Islam MN, Dybek M, Roth E, Heisinger S, Holy M, Jäntsch K, Walther D, Stockner T, Baumann MH, Brandt SD, Wallach J, Sitte HH, Kudlacek O.   +13 more
europepmc   +1 more source

Stress-Induced Dysregulation of Brain Iron Metabolism and Its Links to Neurological Disorders. [PDF]

Biology (Basel)
Dong K, Liu B, Cheng G, Li Y, Xie F, Zhang J, Qian L.   +6 more
europepmc   +1 more source

Structural basis for pharmacotherapeutic action of triple reuptake inhibitors. [PDF]

Nat Commun
Li Y, Meng Y, Li N, Zhao J, Li R, Bai Q, Wang G, Zhao Y.   +7 more
europepmc   +1 more source

Cell membrane cholesterol affects serotonin transporter efflux due to altered transporter oligomerization. [PDF]

Mol Psychiatry
Rudin D, Luethi D, Niello M, Yang JW, Burger I, Sandtner W, Birner-Gruenberger R, Schütz GJ, Sitte HH.   +8 more
europepmc   +1 more source

Harnessing brain rhythms to activate the glymphatic pathway via controlled breathing and intermittent CO₂. [PDF]

J Cereb Blood Flow Metab
Vakhtin AA, Lin HC, Pirio Richardson SE, Shaff NA, Ryman SG.   +4 more
europepmc   +1 more source

Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases. [PDF]

Biology (Basel)
Bao Y, Miao G, He N, Bao X, Shi Z, Hu C, Liu X, Wang B, Sun C.   +8 more
europepmc   +1 more source