Results 91 to 100 of about 180,517 (218)

Obesity and hypoxia have differential effects on myocardial innervation in the right ventricle of the male mouse heart

Journal of Anatomy, EarlyView.
Obesity induced by a high fat diet caused hyperinnervation of the right ventricle, whereas chronic hypoxia alone did not significantly alter right ventricular innervation. Surprisingly, chronic hypoxia attenuated the obesity‐induced changes in right ventricular innervation.
Louisa‐Chiara Mierswa, Julia Schipke, Christian Mühlfeld   +2 more
wiley   +1 more source

Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin [PDF]

, 2015
Many solute carrier 6 (SLC6) family transporters require ancillary subunits to modify their expression and activity. The main apical membrane neutral amino acid transporters in mouse intestine and kidney, B(0)AT1 and B(0)AT3, require the ancillary ...
Broeer, Angelika, Broeer, Stefan, Cheng, Qi, Fairweather, Stephen J., O'Mara, Megan L., Schmoll, Dieter, Subramanian, Nandhitha, Turner, Ennrah   +7 more
core   +2 more sources

Endoplasmic Reticulum-Plasma Membrane Contact Sites.

Annual Review of Biochemistry, 2017
The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM).
Yasunori Saheki, P. De Camilli
semanticscholar   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, James Andrew, Mastitskaya Svetlana   +2 more
wiley   +1 more source

Synaptic-like microvesicles, synaptic vesicle counterparts in endocrine cells, are involved in a novel regulatory mechanism for the synthesis and secretion of hormones [PDF]

, 2001
Microvesicles in endocrine cells are the morphological and functional equivalent of neuronal synaptic vesicles. Microvesicles accumulate various neurotransmitters through a transmitter-specific vesicular transporter energized by vacuolar H+-ATPase.
Hayashi, Mitsuko, Ishio, Shougo, Moriyama, Yoshinori, Yamada, Hiroshi, Yamamoto, Akitsugu, Yatsushiro, Shouki   +5 more
core  

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. [PDF]

, 2009
Uptake through the dopamine transporter (DAT) represents the primary mechanism used to terminate dopaminergic transmission in brain. Although it is well known that dopamine (DA) taken up by the transporter is used to replenish synaptic vesicle stores for
Baust, Tracy B, Cuevas, Rolando A, Dorostkar, Mario M, Egaña, Loreto A, Hochendoner, Sarah, Hong, Weimin C, Janz, Roger, Leak, Rehana K, Parra, Leonardo A, Peña, Karina, Quiroz, Marisol, Sitte, Harald H, Torres, Gonzalo E   +12 more
core   +1 more source

Does Plasmodium falciparum have an Achilles' heel? [PDF]

Malaria Chemotherapy, Control, and Elimination 3, 114 (2014). DOI: 10.4172/2090-2778.1000114, 2013
Plasmodium falciparum is the parasite that causes the most severe form of malaria. Currently, science has been established about its cellular structures, its metabolic processes, and even the molecular structures of its intrinsic membrane proteins responsible for transporting water, nutrient, and waste molecules across the parasite plasma membrane (PPM)
arxiv  

Kinetic Analysis of Secretory Protein Traffic and Characterization of Golgi to Plasma Membrane Transport Intermediates in Living Cells

Journal of Cell Biology, 1998
Quantitative time-lapse imaging data of single cells expressing the transmembrane protein, vesicular stomatitis virus ts045 G protein fused to green fluorescent protein (VSVG–GFP), were used for kinetic modeling of protein traffic through the various ...
K. Hirschberg, Chad M. Miller, J. Ellenberg, J. Presley, E. Siggia, R. Phair, J. Lippincott-Schwartz   +6 more
semanticscholar   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Relaxing the aquaporin crystal structure in a membrane with surface vibrational spectroscopy [PDF]

arXiv, 2019
High-resolution structural information on membrane proteins is essential for understanding cell biology and for structure-based design of new medical drugs and drug delivery strategies. X-ray diffraction (XRD) can provide {\AA}ngstrom-level information about the structure of membrane proteins. Ideally protein structures should be solved in environments
arxiv