Results 31 to 40 of about 180,517 (218)
Malaria Journal, 2009 BackgroundThe spread of drug resistance has been a major obstacle to the control of malaria. The mechanisms underlying drug resistance in malaria seem to be complex and multigenic. The current literature on multiple drug resistance against anti-malarials
R. Kavishe +5 more
semanticscholar +1 more source
Machine learning analysis of cocaine addiction informed by DAT, SERT, and NET-based interactome networks [PDF]
arXiv, 2022 Cocaine addiction is a psychosocial disorder induced by the chronic use of cocaine and causes a large of number deaths around the world. Despite many decades' effort, no drugs have been approved by the Food and Drug Administration (FDA) for the treatment of cocaine dependence. Cocaine dependence is neurological and involves many interacting proteins in
arxiv
Healthy sweet inhibitor of Plasmodium falciparum aquaglyceroporin [PDF]
Biophysical Chemistry 198, 14-21 (2015), 2013 Plasmodium falciparum aquaglyceroporin (PfAQP) is a multifunctional channel protein in the plasma membrane of the malarial parasite that causes the most severe form of malaria infecting more than a million people a year. Finding a novel way to inhibit PfAQP, I conducted 3+ microseconds in silico experiments of an atomistic model of the PfAQP-membrane ...
arxiv +1 more source
Biochemical Journal, 1990 Plasma membrane- and Golgi vesicle-enriched membrane fractions were prepared from day-10 lactating rat mammary glands. Each fraction was found to contain a single set of D-glucose-inhibitable cytochalasin B-binding sites: plasma membranes and Golgi ...
Rustom J. Madon +5 more
semanticscholar +1 more source
Collective Molecular Dynamics in Proteins and Membranes [PDF]
Biointerphases Volume 3, Issue 2, pp. FB83-FB90 (June 2008), 2008 The understanding of dynamics and functioning of biological membranes and in particular of membrane embedded proteins is one of the most fundamental problems and challenges in modern biology and biophysics. In particular the impact of membrane composition and properties and of structure and dynamics of the surrounding hydration water on protein ...
arxiv +1 more source
Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells. [PDF]
, 1994 Neurons and endocrine cells have two types of secretory vesicle that undergo regulated exocytosis. Large dense core vesicles (LDCVs) store neural peptides whereas small clear synaptic vesicles store classical neurotransmitters such as acetylcholine ...
Edwards, RH +5 more
core
Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management
Advanced Science, EarlyView.Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang +4 more
wiley +1 more source
Rat white adipocytes activate p85/p110 PI3K and induce PM GLUT4 in response to adrenoceptor agonists or aluminum fluoride [PDF]
, 2016 Adipocyte responses to adrenergic and ß-adrenoceptor(-AR) (adrenoceptor) regulation are not sufficiently understood, and information helpful for elucidating the adrenoceptor-responsive machinery is insufficient.
Nomura, Y, Ohsaka, Y
core +1 more source
Hydrodynamics of bilayer membranes with diffusing transmembrane proteins [PDF]
Soft Matter, 12, 1791-1800 (2016), 2016 We consider the hydrodynamics of lipid bilayers containing transmembrane proteins of arbitrary shape. This biologically-motivated problem is relevant to the cell membrane, whose fluctuating dynamics play a key role in phenomena ranging from cell migration, intercellular transport, and cell communication. Using Onsager's variational principle, we derive
arxiv +1 more source
Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury
Advanced Science, EarlyView.The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He +11 more
wiley +1 more source