Results 71 to 80 of about 180,517 (218)

Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi

British Journal of Pharmacology, EarlyView.
Background and Purpose Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED). We hypothesized that vitamin D deficiency or vitamin D receptor (VDR) knockout causes ED and analysed the underlying molecular mechanisms.
Miguel A. Olivencia, Belén Climent, Bianca Barreira, Daniel Morales‐Cano, Ana Sánchez, Argentina Fernández, Borja García‐Gómez, Javier Romero‐Otero, Claudia Rodríguez, Laura Moreno, Dolores Prieto, María Jesús Larriba, Angel Cogolludo, Javier Angulo, Francisco Perez‐Vizcaino   +14 more
wiley   +1 more source

Characterization of the norepinephrine-activation of adenylate cyclase suggests a role in memory affirmation pathways. Overexposure to epinephrine inactivates adenylate-cyclase,a causal pathway for stress-pathologies [PDF]

BioSystems 100 (2010) p. 87-93, 2010
Incubation with noradrenaline (norepinephrine) of isolated membranes of rat's brain corpus striatum and cortex, showed that ionic-magnesium (Mg2+) is required for the neurotransmitter activatory response of Adenylate Cyclase [ATP pyrophosphate-lyase (cyclizing), (EC 4.6.1.1)], AC.An Mg2+-dependent response to the activatory effects of adrenaline, and ...
arxiv  

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

British Journal of Pharmacology, EarlyView.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio, Luiz G. S. Branco, Fernanda Brognara, Patrícia Passaglia, Roberta Foresti, Roberto Motterlini   +5 more
wiley   +1 more source

GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET [PDF]

, 2009
The mouse γ-aminobutyric acid (GABA) transporter mGAT1 was expressed in neuroblastoma 2a cells. 19 mGAT1 designs incorporating fluorescent proteins were functionally characterized by [^3H]GABA uptake in assays that responded to several experimental ...
Abramoff, Bal, Bal, Bartholomäus, Bauman, Bjerggaard, Blackman, Boudanova, Boyd, Brückner, Chen, Chiu, Chiu, Cole, Corry, Corry, Deken, Doherty, Drenan, Elangovan, Farhan, Farhan, Farhan, Farhan, Feige, Fraser J. Moss, Gauthier, Geiser, Gordon, Guastella, Harris, Hastrup, Henry A. Lester, Hess, Holton, Hu, Hung, Imoukhuede, Jares-Erijman, Jia Hu, Joanna L. Jankowsky, Just, Kanner, Kanner, Kerschensteiner, Khakh, Kilic, Kimberly Scott, Korkhov, Kuryatov, Lakowicz, Lakowicz, Lester, Lester, Li, Lin, Loder, Loo, Madsen, Mager, Manley, Mazei-Robison, McHugh, Melikian, Michael W. Quick, Miranda, Miranda, Morel, Munro, Nashmi, Nashmi, Ormö, P.I. Imoukhuede, Quick, Raicu, Raicu, Ramamoorthy, Reiterer, Reith, Riven, Rizzo, Roux, Rudnick, Rudnick, Sallette, Schmid, Scholze, Sekar, Sheng, Son, Soragna, Sorkina, Spudich, Tadross, Taunton, Tokunaga, Torres, Torres, Wallrabe, Wang, Whitworth, Xia, Yamashita, Zacharias, Zahniser, Zhang   +105 more
core   +3 more sources

Anomalous diffusion of proteins in sheared lipid membranes [PDF]

, 2013
We use coarse grained molecular dynamics simulations to investigate diffusion properties of sheared lipid membranes with embedded transmembrane proteins. In membranes without proteins, we find normal in-plane diffusion of lipids in all flow conditions. Protein embedded membranes behave quite differently: by imposing a simple shear flow and sliding the ...
arxiv   +1 more source

Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour

Biological Reviews, EarlyView.
ABSTRACT Antipsychotic drugs (APDs) are a diverse class of neuroactive pharmaceuticals increasingly detected in surface and ground waters globally. Some APDs are classified as posing a high environmental risk, due, in part, to their tendency to bioaccumulate in wildlife, including fish.
Gabrielle Wasser‐Bennett, A. Ross Brown, Samuel K. Maynard, Stewart F. Owen, Charles R. Tyler   +4 more
wiley   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. [PDF]

, 2019
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes.
A Balkow, A Bartelt, AM Cypess, Ayano Ueno, B Tasic, C Jang, Carlos Henrique Sponton, CB Newgard, CB Newgard, CJ Lynch, CR Green, CT Ferrara, DE Lackey, EG Sustarsic, F Palmieri, Francis C. Szoka, H Ohno, Haruya Takahashi, Hiroko Maki, Homa Majd, Huixia Li, K Ikeda, K Shinoda, Kaori Igarashi, Kazuki Tajima, KC Das, Kenji Ikeda, KH Pietiläinen, KM Huffman, Kyeongkyu Kim, LA Gilbert, Labros Sidossis, M Chondronikola, M Rosell, M Saito, M Wallace, MA Herman, Maki Ohishi, Mami Matsushita, Maria Chondronikola, Masayuki Saito, MD Neinast, Michael T. McManus, Mito Kuroda, Momoko Yoneshiro, Olga R. Ilkayeva, P She, Phillip J. White, PJ White, PJ White, Qiang Wang, Rachana N. Pradhan, Robert W. McGarrah, SH Um, Shingo Kajimura, T Li, T Soga, T Soga, T Yoneshiro, Takamasa Ishikawa, Takeshi Yoneshiro, Teruo Kawada, TJ Wang, Tomoyoshi Soga, Tsuyoshi Goto, V Ouellet, Vanille Juliette Greiner, X Kong, Yann Deleye, Yasuo Oguri, Yong Chen, Zachary Brown, Zhipeng Dai   +72 more
core   +1 more source

Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions*

Journal of Biological Chemistry, 2015
Background: Mechanisms coupling phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) hydrolysis to its rapid replenishment remain elusive. Results: Phosphatidic acid production triggers PIP2 replenishment mediated by Nir2 and Nir3 at endoplasmic reticulum ...
Chi-Lun Chang, J. Liou
semanticscholar   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source