Results 81 to 90 of about 5,761 (235)

Development and Application of HPLC-MS/MS Method for Determination of Human Pharmaceuticals and Synthetic Hormones in River Water and Sewage Effluents [PDF]

open access: yes, 2010
Pollution of the aquatic environment by residues of human pharmaceuticals and synthetic hormones has become a cause for increasing concern in recent years and acknowledged as one of the most emerging environmental issues.
Al-Odaini, Najat Ahmed
core  

Clinical Significance of Drug–Drug Interaction Studies During Therapeutic Peptide Drug Development: Follow‐Up Investigation of Therapeutic Peptides Approved Between 2021 and 2024

open access: yesClinical and Translational Science, Volume 18, Issue 7, July 2025.
ABSTRACT The risk of clinically relevant drug–drug interactions (DDIs) for therapeutic peptides remains unclear, mandating a comprehensive analysis for this modality. In our prior study, we analyzed DDIs for 31 peptide drugs approved between January 2008 and August 2021.
Carolina Säll   +6 more
wiley   +1 more source

Menstrual disturbances in perimenopausal women: What's best? [PDF]

open access: yes, 2009
It's best to start with nonsteroidal anti- inflammatory drugs (NSAIDs), which effectively reduce heavy menstrual bleeding (strength of recommendation [SOR]: B, systematic review of randomized clinical trials [RCTs]).
Chen, Edward C.   +2 more
core  

Actual contamination of the Danube and Sava Rivers at Belgrade (2013) [PDF]

open access: yes, 2014
This study was focussed on a comprehensive investigation on the state of pollution of the Danube and Sava Rivers in the region of Belgrade. Different complementary analytical approaches were employed covering both i) organic contaminants in the river ...
Antonijević, Milan D.   +22 more
core   +2 more sources

Drug–Drug Interaction Potential of Mavacamten with Midazolam: Combined Results from Clinical and Model‐Based Studies

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 5, Page 598-606, May 2025.
Abstract Mavacamten is a potential inducer of cytochrome P450 (CYP) 3A4 and could reduce the effectiveness of concomitant drugs that are metabolized by CYP3A4, such as midazolam. This study aimed to determine if repeat doses of mavacamten achieving clinically relevant exposures affected midazolam exposure.
Samira Merali   +5 more
wiley   +1 more source

Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life [PDF]

open access: yes, 1987
To determine the origin of estrogens in infant blood, we measured estrone (E1) and estradiol (E2) in the gonads of 50 girls and 64 boys who died suddenly between birth and 2 yr of age as well as in the adrenals of 18 of these infant girls and 16 of the ...
Bidlingmaier, F.   +4 more
core   +1 more source

Recent Developments in Deep Eutectic Solvents Applications in Liquid Chromatography: 2019–2025

open access: yesJournal of Separation Science, Volume 48, Issue 5, May 2025.
ABSTRACT Deep eutectic solvents (DES) are used as mobile phase and stationary phase modifiers, or as for the stationary phase itself for thin layer/liquid/supercritical chromatography. Their specific properties can improve the separation selectivity, reduce peak tailing, and shorten the separation time.
Derya Demir   +3 more
wiley   +1 more source

Biodegradable hollow fibres for the controlled release of hormones [PDF]

open access: yes, 1987
Poly(l-lactide), (PLLA), hollow fibres were prepared using a dry-wet phase inversion spinning process. The effect of several spinning parameters (i.e. bore medium flow rate, spinning dope extrusion rate, fibre take-up rate, and spinning height) on the ...
Albers, J.H.M.   +5 more
core   +3 more sources

Ovarian function during hormonal contraception assessed by endocrine and sonographic markers: a systematic review [PDF]

open access: yes, 2016
This systematic review focuses on the literature evidence for residual ovarian function during treatment with hormonal contraceptives. We reviewed all papers which assessed residual ovarian activity during hormonal contraceptive use, using endocrine ...
Bastianelli, Carlo   +5 more
core   +1 more source

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