Results 41 to 50 of about 401,712 (176)

Medroxyprogesterone acetate inhibits wound closure of human endometrial epithelial cells and stromal fibroblasts in vitro

Scientific Reports, 2021
Mucosal integrity in the endometrium is essential for immune protection. Since breaches or injury to the epithelial barrier exposes underlying tissue and is hypothesized to increase infection risk, we determined whether endogenous progesterone or three ...
Mickey V. Patel, Marta Rodriguez-Garcia, Zheng Shen, Charles R. Wira   +3 more
doaj   +1 more source

Norethindrone is superior to combined oral contraceptive pills in short-term delay of menses and onset of breakthrough bleeding: a randomized trial

BMC Women's Health, 2019
Background To determine whether oral norethindrone acetate is superior to combined oral contraceptives (OCP) in delaying menstruation and preventing breakthrough bleeding when started late in the cycle.
Joshua Dean, Katherine J. Kramer, Fauzia Akbary, Shaunte Wade, Maik Hüttemann, Jay M. Berman, Maurice-Andre Recanati   +6 more
doaj   +1 more source

Managing Menopausal Skin Changes: A Narrative Review of Skin Quality Changes, Their Aesthetic Impact, and the Actual Role of Hormone Replacement Therapy in Improvement. [PDF]

J Cosmet Dermatol
ABSTRACT Background The decline in estrogen during menopause contributes to structural and functional skin changes, including decreased collagen production, reduced elasticity, and moisture loss, resulting in dryness and wrinkling. Today, hormone replacement therapy (HRT) enhances skin quality by promoting collagen synthesis, elasticity, and hydration.
Viscomi B, Muniz M, Sattler S.
europepmc   +2 more sources

Reversible interventions for menstrual management in adolescents and young adults with gender incongruence

Therapeutic Advances in Reproductive Health, 2023
The newly released World Professional Association for Transgender Health Standards of Care, 8th Edition specify that adolescents should be offered menstrual suppression as part of their treatment plans to suppress menses and alleviate dysphoria, provide ...
Rosemary Claire Roden
doaj   +1 more source

Tanshinone-I for the treatment of uterine fibroids: Molecular docking, simulation, and density functional theory investigations

Saudi Pharmaceutical Journal, 2023
Uterine fibroids (UF), most prevalent gynecological disorder, require surgery when symptomatic. It is estimated that between 25 and 35 percent of women wait until the symptoms have worsened like extended heavy menstrual bleeding and severe pelvic pain ...
Abhishek Tiwari, Varsha Tiwari, Ajay Sharma, Deependra Singh, Manju Singh Rawat, Tarun Virmani, Reshu Virmani, Girish Kumar, Manish Kumar, Abdulsalam Alhalmi, Omar M. Noman, Ramzi A. Mothana, Mohammad Alali   +12 more
doaj   +1 more source

Development of relugolix combination therapy as a medical treatment option for women with uterine fibroids or endometriosis

F&S Reports, 2023
Treatment of uterine fibroids (UF) and endometriosis (EM) has relied on the surgical skills of gynecologists to improve symptoms and potentially alter the course of these debilitating diseases.
Juan C. Arjona Ferreira, M.D., Elizabeth Migoya, Pharm.D.   +1 more
doaj   +1 more source

Efficacy of hormonal therapies for decreasing uterine volume in patients with adenomyosis

Gynecology and Minimally Invasive Therapy, 2018
Study objective: The aim of this study is to evaluate the efficacy of hormonal therapies for inhibiting an increase in uterine volume in patients with adenomyosis. Design: This was retrospective cohort study.
Takashi Matsushima, Shigeo Akira, Takehiko Fukami, Koichi Yoneyama, Toshiyuki Takeshita   +4 more
doaj   +1 more source

Effect of Elagolix Exposure on Clinical Efficacy End Points in Phase III Trials in Women With Endometriosis‐Associated Pain: An Application of Markov Model

CPT: Pharmacometrics & Systems Pharmacology, 2020
Elagolix is an oral gonadotropin‐releasing hormone antagonist approved by the US Food and Drug Administration (FDA) for the management of moderate‐to‐severe pain associated with endometriosis and in combination with estradiol/norethindrone acetate ...
Insa Winzenborg, Akshanth R. Polepally, Ahmed Nader, Nael M. Mostafa, Peter Noertersheuser, Juki Ng   +5 more
doaj   +1 more source

Colorimetric Analysis of Norethindrone, Norethindrone Acetate, and Norgestrel in Oral Contraceptives

Journal of AOAC INTERNATIONAL, 1970
Abstract A colorimetric method, based on reaction with blue tetrazolium, has been devised for the analysis of norethindrone, norethindrone acetate, and norgestrel. The technique is selective for these progestins, showing no interference from the estrogens ethinyl estradiol and mestranol, commonly found in oral contraceptives.
Shuing Carol Liu, Thomas H Hassall, Robert V Smith   +2 more
openaire   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source