Results 91 to 100 of about 9,879,737 (342)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Normalizers and self-normalizing subgroups

Glasnik matematicki, 2011
Let $\mathbb K$ be a field of characteristic $\neq 2$. Suppose $G=\boldsymbol{; ; G}; ; (\mathbb K)$ is the group of $\mathbb K$-points of a reductive algebraic $\mathbb K$-group $\boldsymbol{; ; G}; ; $. Let $G_1\leq G$ be the group of $\mathbb K$-points of a reductive subgroup $\boldsymbol{; ; G}; ; _1\leq \boldsymbol{; ; G}; ; $.
openaire   +4 more sources

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

Robustness of analysis of covariance (ancova) under the distributions assumptions and variance homogeneity [PDF]

Eurasian Journal of Veterinary Sciences, 2020
Aim: As in all parametric methods, the ANCOVA method assumes that normal distributions of errors, homogeneity of variances, and error terms are independent of each other. However, unusual distributions in practice are more common than normal distribution.
Can Ateş, Özlem Kaymaz, Mustafa Agah Tekindal, Beyza Doğanay Erdoğan   +3 more
doaj  

Non‐normal data: Is ANOVA still a valid option?

Psicothema, 2017
Background: The robustness of F‐test to non‐normality has been studied from the 1930s through to the present day. However, this extensive body of research has yielded contradictory results, there being evidence both for and against its robustness.
M. Blanca, R. Alarcón, J. Arnau, Roser Bono, R. Bendayan   +4 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

INTERVAL-VALUED INTUITIONISTIC FUZZY BI-IDEALS IN TERNARY SEMIRINGS [PDF]

Romanian Journal of Mathematics and Computer Science, 2016
In this paper we introduce the notions of interval-valued fuzzy bi-ideal, interval-valued anti fuzzy bi-ideal and interval-valued intuitionistic fuzzy bi-ideal in ternary semirings and some of the basic properties of these ideals are investigated.
D. KRISHNASWAMY, J. JAYARAJ, T. ANITHA
doaj  

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

La locura en la vida normal

Revista Wimb Lu, 2015
El tema de la locura ha estado presente a lo largo de la historia del ser humano; su concepto y definición han evolucionado de manera paralela a la evolución cultural y social que éste ha sufrido con el transcurrir de los siglos.
Mónica Cruz Alvarado
doaj