Results 241 to 250 of about 9,879,737 (342)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Optimization of thermal barrier coating with induced copper oxide nanoparticles in CI engine using algae methyl ester as fuel. [PDF]

Sci Rep
Prabhahar M, Prakash S, Dharsan P, Elumalai PV, Xueyi F, Hasan N.   +5 more
europepmc   +1 more source

High burden and pervasive positive selection of somatic mutations in normal human skin

Science, 2015
I. Martincorena, A. Roshan, M. Gerstung, P. Ellis, P. Van Loo, Stuart Mclaren, D. Wedge, A. Fullam, L. Alexandrov, J. Tubío, L. Stebbings, A. Menzies, S. Widaa, M. Stratton, P. Jones, P. Campbell   +15 more
semanticscholar   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Effect of oxytocin on cardiovascular modulation in normal and post-traumatic stress disorder model rats. [PDF]

Sci Rep
Yan H, Huang B, Huang S, Zhuang Y, Chen Q, Lan Q, Zhou P, Peng S, Zhang C.   +8 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Deep learning-based video analysis for automatically detecting penetration and aspiration in videofluoroscopic swallowing study. [PDF]

Sci Rep
Kwak S, Kim JK, Moon JS, Lee GW, Kim S, Chang MC.   +5 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Free Methylglyoxal and Lactate Produced and Released by Cultured Cancer and Non-Cancer Cells: Implications for Tumor Growth and Development. [PDF]

Cells
Belpomme D, Irigaray P, Alberto JM, Poletti C, Hinault-Boyer C, Lacomme S.   +5 more
europepmc   +1 more source

The Occurrence of Antibodies for Pneumococcus Type II in the Serum of Normal Rabbits

, 1949
Joaquin Munoz, Frances E. Holford
openalex   +1 more source