Results 81 to 90 of about 6,196,101 (334)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
A frictional contact problem with damage and adhesion for an electro elastic-viscoplastic body
Electronic Journal of Differential Equations, 2014 We consider a quasistatic frictional contact problem for an electro elastic-viscopalastic body with damage and adhestion. The contact is modelled with normal compliance.
Adel Aissaoui, Nacerdine Hemici
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Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Model and analysis for quasistatic frictional contact of a 2D elastic bar
Electronic Journal of Differential Equations, 2018 This article constructs and analyzes a mathematical model that describes the quasistatic evolution of a 2D elastic bar that may come in frictional contact with a deformable foundation.
Mircea Sofonea, Meir Shillor
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When Does Government Limit the Impact of Voter Initiatives? [PDF]
, 2004 Citizens use the initiative process to make new laws. Many winning initiatives, however, are altered or ignored after Election Day. We examine why this is, paying particular attention to several widely-ignored properties of the post-election phase of the
Gerber, Elisabeth R.
core +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Analysis of a rate-and-state friction problem with viscoelastic materials
Electronic Journal of Differential Equations, 2017 We consider a mathematical model which describes the frictional contact between a viscoelastic body and a foundation. The contact is modelled with normal compliance associated to a rate-and-state version of Coulomb's law of dry friction. We start by
Flavius Patrulescu, Mircea Sofonea
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Dynamic contact of two Gao beams
Electronic Journal of Differential Equations, 2012 The dynamic contact of two nonlinear Gao beams that are connected with a joint is modeled, analyzed, and numerically simulated. Contact is modeled with either (i) the normal compliance condition, or (ii) the unilateral Signorini condition.
Jeongho Ahn +2 more
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