Results 51 to 60 of about 2,502,460 (317)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

Normal form of double-Hopf singularity with 1:1 resonance for delayed differential equations

open access: yesNonlinear Analysis, 2019
In this manuscript, we provide a framework for the double-Hopf singularity with 1:1 resonance for general delayed differential equations (DDEs). The corresponding normal form up to the third-order terms is derived.
Xiaoqin P. Wu, Liancheng Wang
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Normalization of equation with linear distributed delay

open access: yesМоделирование и анализ информационных систем, 2009
Some properties of the dynamics of a differential equation with the linear distributed delay is studied. In critical cases, which all have an infinite dimension, special equations - normal forms - were built.
I. S. Kashchenko
doaj  

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Local Dynamics of an Equation with Large Exponential Distributed Delay

open access: yesМоделирование и анализ информационных систем, 2011
We study properties of local dynamics of a differential equation with exponentially distributed delay. In critical cases we built special evolutionary equations.
I. S. Kashchenko
doaj  

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Planetary Birkhoff normal forms

open access: yesJournal of Modern Dynamics, 2011
Birkhoff normal forms for the (secular) planetary problem are investigated. Existence and uniqueness is discussed and it is shown that the classical Poincare variables and the ʀᴘs-variables (introduced in [6]), after a trivial lift, lead to the same Birkhoff normal form; as a corollary the Birkhoff normal form (in Poincare variables) is degenerate
Chierchia L., Pinzari G.
openaire   +5 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Periodic cycles in the Solow model with a delay effect

open access: yesMathematical Modelling and Analysis, 2019
The three natural modifications of the known mathematical macroeconomics model of macroeconomics are studied in which a delay factor is presumed. This led to the replacement of the ordinary differential equation, which cannot exhibit periodic cycles on ...
Anatolij Kulikov   +2 more
doaj   +1 more source

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