Results 111 to 120 of about 84,144,549 (259)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Far East Journal of Dynamical Systems
The Far East Journal of Dynamical Systems is a peer-reviewed international journal, which publishes original research papers and survey articles in all aspects of Dynamical Systems.
LENCI, MARCO
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Analysis of dynamical systems via normal forms
, 2015 Desde hace muchos años los problemas de la dinámica han sido objeto de estudio por científicos de distintas épocas. Podemos decir que los sistemas dinámicos se ocupan del estudio de los modelos de evolución de los sistemas en un cierto espacio (espacio de fases).
openaire +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Dynamics of physical systems , normal forms and Markov chains
Dynamique des systèmes physiques, formes normales et chaînes de Markov Cette thèse porte sur le comportement asymptotique des systèmes dynamiques et contient cinq chapitres indépendants.Nous considérons dans la première partie de la thèse trois systèmes dynamiques concrets. Les deux premiers chapitres présentent deux modèles de systèmes
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Observer-based adaptive fuzzy-neural control for unknown nonlinear dynamical systems
, 2013 [[abstract]]In this paper, an observer-based adaptive fuzzy-neural controller for a class of unknown nonlinear dynamical systems is developed. The observer-based output feedback control law and update law to tune on-line the weighting factors of the ...
Y.-G. Leu;T.-T. Lee;W.-Y. Wang
core
Dynamical systems and normal forms of complex structures along submanifolds
Dynamical systems and normal forms of complex structures along submanifolds学位記番号：論理学第1号, 主査：伊師 ...
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Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source