Results 191 to 200 of about 1,366,906 (287)

Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention.

Proceedings of the National Academy of Sciences of the United States of America, 2000
J. Swanson, J. Oosterlaan, M. Murias, S. Schuck, P. Flodman, M. Spence, M. Wasdell, Y. Ding, H. Chi, M. Smith, M. Mann, C. Carlson, J. Kennedy, J. Sergeant, P. Leung, Ye Zhang, A. Sadeh, C. Chen, C. Whalen, K. A. Babb, R. Moyzis, M. Posner   +21 more
semanticscholar   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Agreement of thermodilution and direct Fick methods for cardiac output across varying haemodynamic conditions. [PDF]

ESC Heart Fail
Melin M, Löfman IH, Matan D, Nygren M, Shahim B, Lund LH, Manouras A.   +6 more
europepmc   +1 more source

Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health.

American Journal of Clinical Nutrition, 2016
J. Walsh, A. Evans, S. Bowles, K. Naylor, K. Jones, I. Schoenmakers, R. Jacques, R. Eastell   +7 more
semanticscholar   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

The Effect of Cranberry Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Clin Cardiol
Bahreyni LZ, Amini MR, Sheikhi L, Taheri E, Rahimi P, Samarin MM, Sheikhhossein F, Etesamnia S, Lohrasbi N, Hekmatdoost A.   +9 more
europepmc   +1 more source

Machine‐Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles

Advanced Science, EarlyView.
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang, Ji Chen, Jinfeng Han, Wei Cheng, Jiang Qiu, Jianfeng Feng, Simon Eickhoff, Deniz Vatansever   +7 more
wiley   +1 more source

Reduced dose versus standard melphalan conditioning for autologous stem cell transplantation in multiple myeloma: a single-center retrospective study. [PDF]

Ann Hematol
Yao Y, Zhang S, Li Z, Luo L, Lu X, Wang H.   +5 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Association between maximal lower leg strength and static and dynamic balance as well as gait velocity in older adults. [PDF]

Front Aging
Warneke K, Stotz A, Konrad A, Zech A.
europepmc   +1 more source