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EGR1 lactylation induces tumor cell senescence and immunosuppressive microenvironment in intrahepatic cholangiocarcinoma. [PDF]

open access: yesTransl Oncol
Liang Y   +14 more
europepmc   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

open access: yesAdvanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu   +11 more
wiley   +1 more source
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Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin Within the Normal Range and Normalization of Alkaline Phosphatase.

American Journal of Gastroenterology, 2020
OBJECTIVES In primary biliary cholangitis (PBC), bilirubin and alkaline phosphatase (ALP) are widely established as independent predictors of prognosis.
C. F. Murillo Perez   +28 more
semanticscholar   +1 more source

The lattice of generalized normal L-subgroups

Journal of Intelligent & Fuzzy Systems, 2014
Many studies have investigated the lattice structure of fuzzy substructures of algebraic sets such as group and ring. Some important results about modularity and distributivity have been obtained in these studies. In this paper, we first define the notion of (normal) (λ,μ)-L-subgroups on a group and investigate some of their properties.
Bayrak, Dilek, Yamak, Sultan
openaire   +1 more source

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