Results 141 to 150 of about 3,724,631 (298)

Correlations of the normal modes.

, 2012
Correlation function of the displacements of two atoms separated by an angle calculated for the normal modes of (A) 11-mer TRAP and (B) 12-mer TRAP. The vertical broken lines indicate the location of the subunit interfaces. The plots are for the normal
Yasuhiro Matsunaga (118244), Motonori Ota (3064), Jeremy R. H. Tame (118250), Akinori Kidera (118253), Ryotaro Koike (118247)   +4 more
core   +1 more source

Resonance Modes of Water Drops Pinned to a Vibrating Rectangular Post

Micromachines
We studied the effects of vertical vibrations on a water drop that was pinned to the sharp edges of a rectangular post. By varying the frequency and amplitude of the vertical displacement, distinct resonance peaks were observed using a simple optical ...
Paolo Sartori, Davide Ferraro, Matteo Pierno, Giampaolo Mistura   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Vibronic effects accelerate the intersystem crossing processes of the through-space charge transfer states in the triptycene bridged acridine-triazine donor-acceptor molecule TpAT-tFFO. [PDF]

Chem Sci, 2022
Kaminski JM, Rodríguez-Serrano A, Dinkelbach F, Miranda-Salinas H, Monkman AP, Marian CM.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

[Commencement Program for Normal College Training School, May 27, 1922]

, 1922
Commencement Program for Normal College Training School on May 27, 1922. The program is printed on cardstock and the program reads, "Commencement Program. Normal Training School. Saturday, May 27, 1922. Nine O'Clock. 1. Opening Chorus...Ninth Grade.
Normal College Training School
core  

[Commencement Exercises North Texas State Normal College]

, 1915
Commencement program for the 1915 graduating class of North Texas State Normal College.
North Texas State Normal College
core   +1 more source

Towards gaining sight of multiscale events: utilizing network models and normal modes in hybrid methods. [PDF]

Curr Opin Struct Biol, 2020
Krieger JM, Doruker P, Scott AL, Perahia D, Bahar I.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source