Results 71 to 80 of about 5,736,037 (284)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Large Scale Structure Formation of Normal Branch in DGP Brane World Model

, 2007
In this paper, we study the large scale structure formation of the normal branch in DGP model (Dvail, Gabadadze and Porrati brane world model) by applying the scaling method developed by Sawicki, Song and Hu for solving the coupled perturbed equations of
A. Cardoso, Yong-Seon Song
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Strong coupling with directional absorption features of Ag@Au hollow nanoshell/J-aggregate heterostructures

Nanophotonics, 2019
Tunable plasmon-exciton coupling is demonstrated at room temperature in hybrid systems consisting of Ag@Au hollow nanoshells (HNSs) and J-aggregates. The strong coupling depends on the exciton binding energy and the localized surface plasmon resonance ...
Sun Linchun, Li Ze, He Jingsuo, Wang Peijie   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Functional differences of short and long isoforms of spastin harboring missense mutation

Disease Models & Mechanisms, 2018
Mutations of the SPG4 (SPAST) gene encoding for spastin protein are the main causes of hereditary spastic paraplegia. Spastin binds to microtubules and severs them through the enzymatic activity of its AAA domain.
Clément Plaud, Vandana Joshi, Natallie Kajevu, Christian Poüs, Patrick A. Curmi, Andrea Burgo   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Normal structure of banach spaces

Manuscripta Mathematica, 1974
GOSSEZ and LAMI DOZO have obtained a sufficient condition for a Banach space with a Schauder basis to have normal structure. This paper generalizes their theorem to obtain a sufficient condition for an arbitrary Banach space to have normal structure. An example is given to show an application of the theorem.
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development

Nature Communications
Despite the importance of keratinocytes in epidermal structure and function, the molecular mechanisms regulating the division of these cells remain poorly understood. Herein, we demonstrate an essential role for cilia and flagella associated protein 100 (
Shuang Sun, Zhaoying Wang, Zhaoyang Xu, Zhengfeng Wang, Jia Sun, Keke Li, Min Liu, Huijie Zhao, Peiwei Liu, Jun Zhou   +9 more
doaj   +1 more source