Results 81 to 90 of about 5,736,037 (284)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Distant two-qubit gates in atomic array with Rydberg interaction using geometric quantum control

open access: yesQuantum Frontiers
Connectivity between qubits plays an irreplaceable role in quantum computation. An urgent task of quantum computation based on atomic arrays is to generate effective coupling between two distant qubits, thereby enhancing connectivity.
Ze-Rui He   +10 more
doaj   +1 more source

Recent Advances in Microfluidic Impedance Detection: Principle, Design and Applications

open access: yesMicromachines
Under the dual drivers of precision medicine development and health monitoring demands, the development of real-time biosensing technologies has emerged as a key breakthrough in the field of life science analytics.
Yigang Shen   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Normal structure and the sum-property [PDF]

open access: yesPacific Journal of Mathematics, 1986
The first permanence result for normal structure is due to Belluce, Kirk and Steine: The \(\ell^ N_{\infty}\)-direct sum of N normally structured normed spaces again has normal structure. The author of this paper continues for discussion on it. For \(Z=(R^ N,| \cdot |)\) with symmetric norm \(| \cdot |\) the Z-direct sum of the normed spaces \(X_ 1,...,
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

A Note on the Kadec-Klee Property

open access: yesAxioms
The objective of this paper is to rigorously define the Kadec-Klee property for modular spaces endowed with a sequential convergence structure, and to demonstrate that this property leads to normal structure in such spaces.
Wojciech M. Kozlowski
doaj   +1 more source

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