Results 81 to 90 of about 63,918 (292)

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

VIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang, Ming Chen, Yi Tian, Bo Qin, Xiaoxiao Chen, Yiwen Zhou, Jinhai Huang, Mei Yang, Xinghuai Sun, Yuan Lei, Yuhong Chen   +10 more
wiley   +1 more source

Glaucomatous optic disc changes despite normal baseline intraocular pressure in a child

American Journal of Ophthalmology Case Reports, 2019
Purpose: We describe a case of normal tension glaucoma in the setting of sickle cell disease in a 9-year-old patient with a five-year follow up. Observations: A 9-year-old male patient with a history of sickle cell disease presented initially at the age ...
Brent B. Hoffman, Eldar Rosenfeld, Alana L. Grajewski, Ta C. Chang   +3 more
doaj  

DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy

Aging Cell, EarlyView.
In normal physiological processes, autophagy acts as a protective factor against aging stress. With the stress increase, the DLK/JNK3 pathway is activated and autophagy is continuously upregulated. In our study, excessive autophagy leads to hair cell senescence, which reveals that excessive autophagy can play a harmful role in senescence under certain ...
Rui Ding, Weiyi Huang, Chenling Shen, Yi Pan, Yiming Zhong, Bing Kong, Yilin Shen, Mingliang Xiang, Bin Ye   +8 more
wiley   +1 more source

Ythdf2 Ablation Protects Aged Retina From RGC Dendrite Shrinking and Visual Decline

Aging Cell, EarlyView.
The m6A reader YTHDF2 regulates retinal degeneration caused by aging, which is mediated by its target mRNAs Hspa12a and Islr2. ABSTRACT Aging‐related retinal degeneration and vision loss have been severely affecting the elderly worldwide. Previously, we showed that the m6A reader YTHDF2 is a negative regulator for dendrite development and protection of
Fugui Niu, Gaoxin Long, Jian Zhang, Jun Yu, Sheng‐Jian Ji   +4 more
wiley   +1 more source

Comparing Healthcare Resource Utilization and Costs for Patients with Normal Tension Glaucoma Across Levels of Severity: A Retrospective Cohort Study

Clinical Ophthalmology, 2021
Brennan Beal,1 Vanessa Shih,2 Joanna Campbell,2 David Veenstra,1 Beth Devine1 1The Comparative Health Outcomes, Policy and Economics (CHOICE) Institute, University of Washington, Seattle, WA, USA; 2Healthcare Economics and Outcomes Research, AbbVie ...
Beal B, Shih V, Campbell J, Veenstra D, Devine B   +4 more
doaj  

EVOLUTION THE CONCEPTS OF ROLE OF INTRAOCULAR PRESSURE IN GLAUCOMA PROGRESSION (REVIEW)

Oftalʹmologiâ, 2016
The role of elevated intraocular pressure (IOP) in the progression of glaucoma optical neuropathy has emphasized repeatedly. The question about the role of elevated IOP as the underlying cause of glaucoma arose in the early 1960s.
N. I. Kurysheva, E. O. Shatalova
doaj   +1 more source

Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma

Scientific Reports, 2020
In meta-analyses, it has been reported that myopia is a risk factor for glaucoma and there is increasing evidence that autonomic dysfunction causing vascular dysregulation or perfusion dysfunction is considered an important factor in the progression of ...
Da-Young Shin, S. Jeon, H. Park, C. Park
semanticscholar   +1 more source

Does Lithium Lower the Risk of Glaucoma—A Danish Nationwide Study

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Glaucoma is an optic neuropathy caused by neurodegenerative loss of retinal ganglion cells (RGC). Mechanisms that contribute to RGC death include some of the same mechanisms involved in bipolar disorders (BD) and are the same mechanisms which are targeted by lithium (Li).
Tomas Hajek, Orestes Forlenza, Marcelo Nicolela, Ann‐Eva Christensen, Henrik Vorum, René Ernst Nielsen   +5 more
wiley   +1 more source

Prototype master protocol for benchmarking of real‐world follow‐up data in glaucoma

Acta Ophthalmologica, EarlyView.
Abstract Purpose The purpose of this study was to create a prototype master protocol for benchmarking glaucoma real‐world data (RWD). Benchmarking is part of the digital innovation strategy of the Finnish aces‐rwm ecosystem (automation of care and evaluation of the system with real‐world monitoring).
Pekko Hujanen, Anja Tuulonen, Sanna Leinonen, Kristian Vepsäläinen, Gauti Jóhannesson, Anu Vaajanen, Eemil Lehtonen, Hannele Uusitalo‐Jarvinen   +7 more
wiley   +1 more source

Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography

Clinical Ophthalmology, 2019
Alex C Onishi, Alison D Treister, Peter L Nesper, Amani A Fawzi, Anupama R Anchala Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USACorrespondence: Anupama R AnchalaDepartment of Ophthalmology, Feinberg ...
Onishi AC, Treister AD, Nesper PL, Fawzi AA, Anchala AR   +4 more
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