Results 71 to 80 of about 324,979 (280)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

“AQUÍ NO PASA NADA”: la corrupción en Macondo

Trayectorias Humanas Trascontinentales, 2020
Este escrito hace el relato de una crónica de hechos de corrupción que se han sucedido en Colombia y que tienen como protagonista principal al presidente de la república.
María Cristina Gómez Isaza
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Searching for the grey zone in Slovak sci-fi literature during the normalisation period [PDF]

Slovenska Literatura
This article analyses the phenomenon of the grey zone as a space for alternative expression in Slovak literature during the late 1970s and throughout the 1980s.
Olha Norba
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

SYSTÈMES COMPTABLES DANS LE CONTEXTE DE LA MONDIALISATION [PDF]

CES Working Papers, 2013
La comptabilité joue un rôle important dans les politiques économiques nationales et internationales et analysées dans le contexte de la mondialisation économique, l’harmonisation des normes comptables, a donné lieu au fil du temps, à une source continue
Loredana Oana Hutanu (Toma)
doaj  

Securitising the Present through the Prism of the Past: State-Building and the Legacy of Interventions in Kosovo and Serbia

Comparative Southeast European Studies, 2022
In this article, the author argues that political actors in Kosovo and Serbia, together with international actors from the UN, NATO, and the EU, have developed strategies of political communication in which the threat or promise of external intervention ...
Distler Werner
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Noise or music? Investigating the usefulness of normalisation for robust sentiment analysis on social media data [PDF]

, 2017
In the past decade, sentiment analysis research has thrived, especially on social media. While this data genre is suitable to extract opinions and sentiment, it is known to be noisy.
De Clercq, Orphée, Desmet, Bart, Hoste, Veronique, Lefever, Els, Van de Kauter, Marjan, Van Hee, Cynthia   +5 more
core   +1 more source