Results 121 to 130 of about 155,801 (328)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Joint Learning of Pre-Trained and Random Units for Domain Adaptation in Part-of-Speech Tagging

open access: yes, 2019
Fine-tuning neural networks is widely used to transfer valuable knowledge from high-resource to low-resource domains. In a standard fine-tuning scheme, source and target problems are trained using the same architecture.
Essafi, Hassane   +4 more
core   +2 more sources

Semiclassical Faddeev approximation for electron loss in fast heavy-ion collisions [PDF]

open access: yes, 1981
. The ionisation of the projectile in collisions with heavy targets is described by means of the Faddeev expansion. The series is cut off after five terms which means an inclusion of higher-order interactions of the electron with both the target and the ...
Jakubaßa-Amundsen, Doris H.
core   +1 more source

Delivering the WISE (Whole Systems Informing Self-Management Engagement) training package in primary care: learning from formative evaluation

open access: yesImplementation Science, 2010
Background The WISE (Whole System Informing Self-management Engagement) approach encompasses creating, finding, and implementing appropriate self-care support for people with long-term conditions.
Protheroe Joanne   +7 more
doaj   +1 more source

Perturbation theory for the evaluation of the normalised cutoff frequencies in radially inhomogeneous fibres

open access: yesElectronics Letters, 1980
A simple perturbation theory has been used to study the normalised cutoff frequencies of radially inhomogeneous fibres. The formalism has been developed with a truncated parabolic-index profile as zero-order solution. Numerical calculations have been carried out for α-profiles and have been found to be in good agreement with more rigorous approaches ...
J. Pigeon   +2 more
openaire   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Synthesis of Statistical Indicators to Evaluate Quality of Life in the Italian Provinces [PDF]

open access: yes
This work remarks the need to carefully evaluate the real importance of each variable used in a multivariate analysis context, with particular regard to cases when an overall performance ranking is the main final purpose.
Massimo Alfonso Russo, Roberto Gismondi
core  

Source-side context-informed hypothesis alignment for combining outputs from machine translation systems [PDF]

open access: yes, 2009
This paper presents a new hypothesis alignment method for combining outputs of multiple machine translation (MT) systems. Traditional hypothesis alignment algorithms such as TER, HMM and IHMM do not directly utilise the context information of the source
Du, Jinhua, Ma, Yanjun, Way, Andy
core   +2 more sources

DeepSQLi: Deep Semantic Learning for Testing SQL Injection

open access: yes, 2020
Security is unarguably the most serious concern for Web applications, to which SQL injection (SQLi) attack is one of the most devastating attacks. Automatically testing SQLi vulnerabilities is of ultimate importance, yet is unfortunately far from trivial
Anna Huang Cheng-Zhi   +15 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

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