Results 131 to 140 of about 155,801 (328)

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

The effect of missing values using genetic programming on evolvable diagnosis [PDF]

open access: yes, 2002
Medical databases usually contain missing values due the policy of reducing stress and harm to the patient. In practice missing values has been a problem mainly due to the necessity to evaluate mathematical equations obtained by genetic programming ...
Kalganova, T, Werner, JC
core  

Computational modelling of Yorùbá numerals in a number-to-text conversion system

open access: yesJournal of Language Modelling, 2014
In this paper, we examine the processes underlying the Yorùbá numeral system and describe a computational system that is capable of converting cardinal numbers to their equivalent Standard Yorùbá number names.
Olúgbénga O. Akinadé   +1 more
doaj   +1 more source

Evaluation of extraction kits and RT-qPCR systems adapted to high-throughput platform for circulating miRNAs

open access: yesScientific Reports, 2015
MicroRNAs regulate gene expression at the post-transcriptional level. Differential expression of miRNAs can potentially be used as biomarkers for early diagnosis and prediction for outcomes.
G. Tan, A. Khoo, L. Tan
semanticscholar   +1 more source

Normalised Precision at Fixed Recall for Evaluating TAR

open access: yesProceedings of the 2024 ACM SIGIR International Conference on Theory of Information Retrieval
A popular approach to High-Recall Information Retrieval (HRIR) is Technology-Assisted Review (TAR), which uses information retrieval and machine learning techniques to aid the review of large document collections. TAR systems are commonly used in legal eDiscovery and medical systematic literature reviews.
Wojciech Kusa   +4 more
openaire   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Evaluation of potential reference genes for real-time qPCR analysis in a biparental beetle, Lethrus apterus (Coleoptera: Geotrupidae)

open access: yesPeerJ, 2017
Hormones play an important role in the regulation of physiological, developmental and behavioural processes. Many of these mechanisms in insects, however, are still not well understood.
N. Nagy   +6 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

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