Results 151 to 160 of about 31,411 (282)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Embedding Patient and Public Involvement in Health Professions Education: Bridging Novelty and Normalisation. [PDF]

Clin Teach
Paxino J, Bolton J, Dushyanthen S, Arnott L, Burns K, Denniston C.   +5 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Do process evaluations open up the 'black box' of implementation interventions in health care? A scoping review. [PDF]

Implement Sci
Bracci EL, Collyer S, Oster C, Lynch E, Olasunkanmi-Alimi T, Bulto LN, Harvey G.   +6 more
europepmc   +1 more source

Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R

, 2008
Emmanuelle Comets, Karl Brendel, France Mentré   +2 more
openalex   +2 more sources

Data normalisation techniques in decision making: case study with TOPSIS method

International Journal of Information and Decision Sciences, 2018
Nazanin Vafaei, Rita Almeida Ribeiro, L. Camarinha-Matos   +2 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A multicentre validation study of the Swedish version of the Normalization Process Theory Measure S-NoMAD. [PDF]

Implement Sci Commun
Åberg AC, Wallin L, Tistad M, Weineland S, Lövgren M, Jess K, Giedraitis V, Lyhagen J.   +7 more
europepmc   +1 more source

Evaluation of a learning collaborative on team-based care: qualitative analysis of coaching calls using normalisation process theory [PDF]

Kathleen M. Thies, Meaghan Angers, Amanda Schiessl, Nashwa Khalid, Kasey Harding, Deborah Ward   +5 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source