Results 161 to 170 of about 155,801 (328)

Assessing temporal complementarity between three variable energy sources by means of correlation and compromise programming

, 2019
Renewable energies are deployed worldwide to mitigate climate change and push power systems towards sustainability. However, the weather-dependent nature of renewable energy sources often hinders their integration to national grids.
Beluco, Alexandre, Canales, Fausto A., Jurasz, Jakub, Kies, Alexander   +3 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Constraints on parity violating conformal field theories in $d=3$

, 2017
We derive constraints on three-point functions involving the stress tensor, $T$, and a conserved $U(1)$ current, $j$, in 2+1 dimensional conformal field theories that violate parity, using conformal collider bounds introduced by Hofman and Maldacena ...
Chowdhury, Subham Dutta, David, Justin R., Prakash, Shiroman   +2 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Strange meson production in Al+Al collisions at 1.9A GeV

, 2016
The production of K$^+$, K$^-$ and $\varphi$(1020) mesons is studied in Al+Al collisions at a beam energy of 1.9A GeV which is close or below the production threshold in NN reactions. Inverse slopes, anisotropy parameters, and total emission yields of K$^
Andronic, A., Averbeck, R., Barret, V., Basrak, Z., Bastid, N., Benabderrahmane, M. L., Berger, M., Buehler, P., Cargnelli, M., Crochet, P., Czerwiakowa, O., Deppner, I., Dupieux, P., Dželalija, M., Fabbietti, L., Fodor, Z., Fèvre, A. Le, Gasik, P., Gašparić, I., Grishkin, Y., Hartmann, O. N., Herrmann, N., Hildenbrand, K. D., Hong, B., Kang, T. I., Kecskemeti, J., Kim, Y. J., Kirejczyk, M., Kiš, M., Koczon, P., Kotte, R., Lebedev, A., Leifels, Y., Liu, J. L., Lopez, X., Manko, V., Marton, J., Matulewicz, T., Münzer, R., Petrovici, M., Piasecki, K., Rami, F., Reischl, A., Reisdorf, W., Ryu, M. S., Schmidt, P., Schüttauf, A., Seres, Z., Sikora, B., Sim, K. S., Simion, V., Siwek-Wilczyńska, K., Smolyankin, V., Suzuki, K., Tymiński, Z., Wagner, P., Weber, I., Widmann, E., Wiśniewski, K., Xiao, Z. G., Yushmanov, I., Zhang, Y., Zhilin, A., Zinyuk, V., Zmeskal, J., Čaplar, R.   +65 more
core   +2 more sources

CYTOKINE ACTIVITY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Российский кардиологический журнал, 2010
Acute myocardial infarction is a severe cardiovascular pathology. Recent studies have demonstrated that its clinical course depends not only on the size of necrosis zone, but also on the local inflammation activity. In this study, the dynamics of various
I. I. Chukaeva, N. V. Orlova, Ya. G. Spiryakina, A. L. Pukhalsky, M. V. Solovyeva   +4 more
doaj  

Deep Learning for Delineation of the Spinal Canal in Whole-Body Diffusion-Weighted Imaging: Normalising Inter- and Intra-Patient Intensity Signal in Multi-Centre Datasets

Bioengineering
Background: Whole-Body Diffusion-Weighted Imaging (WBDWI) is an established technique for staging and evaluating treatment response in patients with multiple myeloma (MM) and advanced prostate cancer (APC).
Antonio Candito, Richard Holbrey, Ana Ribeiro, Christina Messiou, Nina Tunariu, Dow-Mu Koh, Matthew D. Blackledge   +6 more
doaj   +1 more source

OP86 Using normalisation process theory to explore the impact of general practitioners working in or alongside emergency departments in England: qualitative findings from a national mixed methods evaluation [PDF]

, 2021
Arabella Scantlebury, Joy Adamson, Helen Anderson, Heather Leggett, Sarah Voss, Heather Brant, Jonathan Benger   +6 more
openalex   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source