Results 191 to 200 of about 31,411 (282)

Normalisation in life-cycle assessment: consequences of new European factors on decision-making

, 2017
Virgile Aymard, V. Botta-Genoulaz
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Mechanical power normalisation methods to predict ICU mortality: a retrospective cohort study. [PDF]

Ann Intensive Care
Khorasanee R, Sanderson B, Tomarchio E, Collins PD, Del Signore R, Shetty S, Chioccola M, Pugliese F, Collino F, Rose L, Giosa L, Camporota L.   +11 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Co-Designing a Primary Healthcare Intervention to Improve Diabetes Care in Mendoza, Argentina: A Qualitative Case Study. [PDF]

Health Expect
Roberti J, Mazzoni A, Guglielmino M, Silva C, Mazzaresi Y, Falaschi A, Hirschhorn LR, Parker JJ, García-Elorrio E.   +8 more
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Reversible pulmonary hypertension in a patient diagnosed with scurvy. [PDF]

BMJ Case Rep
Berra G, Genecand L, Juillet A, Deux JF, Prada P, Müller H, Roffi M, Beghetti M.   +7 more
europepmc   +1 more source

Normalisation, Evaluation and Verification of the New Zealand Hearing Screening Test.

, 2013
Alice Therese Bowden
openalex   +2 more sources

Efficient Training and Evaluation of Recurrent Neural Network Language Models for Automatic Speech Recognition

IEEE/ACM Transactions on Audio Speech and Language Processing, 2016
Xie Chen, Xunying Liu, Yongqiang Wang, M. Gales, P. Woodland   +4 more
semanticscholar   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source