Results 241 to 250 of about 31,411 (282)

Normalised Precision at Fixed Recall for Evaluating TAR

Wojciech Kusa, Georgios Peikos, Moritz Staudinger, Aldo Lipani, Allan Hanbury   +4 more
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A flexible framework for minimal biomarker signature discovery from clinical omics studies without library size normalisation. [PDF]

PLOS Digit Health
Rawlinson D, Zhou C, Kaforou M, Cao KL, Coin LJM, RAPIDS Study Group.   +5 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Reverse Remodelling, Myocardial Recovery and Remission in Heart Failure with Reduced Ejection Fraction: Clinical Implications and Management Strategies. [PDF]

Card Fail Rev
Furquim SR, Lira MTSS, Belfort DSP, Biselli B, Chizzola PR, Munhoz RT, Bocchi EA, Ayub-Ferreira SM.   +7 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers. [PDF]

Clin Transl Med
Lamia MR, Perri E, Baldassarre G, Pignata S, D'Alessio C, Limongello D, Basso-Valentina F.   +6 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Process evaluation exploring implementation and delivery of a home-based extended exercise intervention for older people with frailty: the HERO trial.

Health Technol Assess
Hall AJ, Ziegler F, Prescott M, Goodwin VA, Hulme C, Farrin AJ, Thompson E, Forster A, Clegg A, Clarke D.   +9 more
europepmc   +1 more source

Sustained engagement with a digital youth mental health platform: A mixed-methods study. [PDF]

Internet Interv
Valentine L, Nicholas J, Sorenson R, Chen NA, McEnery C, Louis S, Cross S, Mangelsdorf SN, O'Sullivan S, Wren TW, Bucci S, Gleeson J, Bendall S, Alvarez-Jimenez M.   +13 more
europepmc   +1 more source